Oxygen-Independent Decarbonylation of Aldehydes by Cyanobacterial Aldehyde Decarbonylase: A New Reaction of Diiron Enzymes

被引：81

作者：

Das, Debasis ^{[1
]}

Eser, Bekir E. ^{[1
]}

Han, Jaehong ^{[2
]}

Sciore, Aaron ^{[1
]}

Marsh, E. Neil G. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Chung Ang Univ, Sch Biol Sci, Anseong 456756, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 31期

基金：

美国国家卫生研究院;

关键词：

biofuels; free radicals; hydrolysis reactions; metalloproteins; radical traps; TRACHOMATIS RIBONUCLEOTIDE REDUCTASE; MANGANESE(IV)/IRON(III) COFACTOR; METHANE MONOOXYGENASE; ELECTRON-TRANSFER; FATTY ALDEHYDE; PISUM-SATIVUM; BIOSYNTHESIS; PLANT; IRON; DIOXYGEN;

D O I：

10.1002/anie.201101552

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Just add water: Structurally, cyanobacterial aldehyde decarbonylases are members of the non-heme diiron oxygenase family of enzymes. However, the enzyme catalyzes the hydrolysis of aliphatic aldehydes to alkanes and formate (see scheme), in an oxygen-independent reaction. This unusual and chemically difficult reaction most likely involves free radical intermediates. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7148 / 7152

页数：5

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