Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII

被引：58

作者：

Guzel-Akdemir, Ozlen ^{[1
]}

Akdemir, Atilla ^{[2
]}

Karali, Nilgun ^{[1
]}

Supuran, Claudiu T. ^{[3
]}

机构：

[1] Istanbul Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34116 Istanbul, Turkey

[2] Bezmialem Vakif Univ, Fac Pharm, Dept Pharmacol, TR-34093 Istanbul, Turkey

[3] Univ Florence, NEUROFARBA Dept, Sez Sci Farmaceut, I-50019 Florence, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 23期

关键词：

ZINC-COMPLEXES; DRUG DESIGN; SCHIFF-BASES; PATENT; ALPHA; DERIVATIVES; CLONING; ANTIBACTERIAL; EXPRESSION; ACTIVATORS;

D O I：

10.1039/c5ob00688k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII - recently validated antitumor drug targets, being much less effective as inhibitors of the off-target cytosolic isoforms CA I and II.

引用

页码：6493 / 6499

页数：7

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