In vitro and clinical evaluation of optical tooth whitening toothpastes

被引:24
作者
Tao, Danying [1 ]
Sun, Jianing N. [2 ]
Wang, Xiaojie [2 ]
Zhang, Qiong [2 ]
Naeeni, Mojgan A. [3 ]
Philpotts, Carole J. [3 ]
Joiner, Andrew [3 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Prevent Dent,Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China
[2] Unilever Oral Care, 66 Linxin Rd, Shanghai 200335, Peoples R China
[3] Unilever Oral Care, Quarry Rd East, Wirral CH63 3JW, Merseyside, England
关键词
Tooth colour; Perception; Aesthetics; SILICA TOOTHPASTE; EFFICACY; COLOR; ABRASION; STAIN;
D O I
10.1016/j.jdent.2017.08.014
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objectives: To measure tooth whitening effects delivered immediately after brushing with silica-based toothpastes containing either blue covarine or a combination of blue covarine and FD&C Blue No. 1 in vitro and in vivo. Methods: Salivary pellicle coated human extracted teeth were brushed with either a slurry of a toothpaste containing blue covarine (BC) or a formulation containing a matched level of blue covarine and FD&C Blue No. 1 (BC + D). The colour of the specimens were measured in vitro using a colorimeter, before and after brushing and changes in CIELAB and tooth Whiteness Index (WIO) values calculated. In a double-blind cross-over clinical study, subjects brushed with BC toothpaste, a toothpaste containing increased levels of blue covarine (BC +) or BC + D toothpaste and tooth colour changes were measured with a digital image analysis system. Results: The in vitro study demonstrated that BC + D gave a significantly (p = 0.002) greater change in WIO value than BC. Clinical results showed that BC, BC + and BC + D gave a significant increase in WIO (p < 0.0001) from baseline. The WIO change was significantly greater when brushing with BC + D toothpaste than with either toothpaste BC (p < 0.0001) or BC + (p < 0.05). Conclusions: Toothpastes containing blue covarine or a combination of blue covarine and FD&C Blue No. 1 gave a statistically significant improvement in tooth whiteness immediately after brushing in both in vitro and clinical studies. In addition, the toothpaste containing both blue covarine and FD&C Blue No. 1 gave statistically significant greater tooth whitening from baseline than the blue covarine containing toothpastes. Clinical significance: The silica-based toothpastes containing blue covarine or a combination of blue covarine and FD&C Blue No. 1 evaluated in the current study gave significant tooth whitening benefits immediately after one brush.
引用
收藏
页码:S25 / S28
页数:4
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