HLE-Inhibitory Alkaloids with a Polyketide Skeleton from the Marine-Derived Fungus Coniothyrium cereale

被引：33

作者：

Elsebai, Mahmoud Fahmi ^{[1
,2
]}

Natesan, Lavanya ^{[1
]}

Kehraus, Stefan ^{[1
]}

Mohamed, Ietidal E. ^{[1
]}

Schnakenburg, Gregor ^{[3
]}

Sasse, Florenz ^{[4
]}

Shaaban, Saad ^{[4
]}

Guetschow, Michael ^{[5
]}

Koenig, Gabriele M. ^{[1
]}

机构：

[1] Univ Bonn, Inst Pharmaceut Biol, D-53115 Bonn, Germany

[2] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura, Egypt

[3] Univ Bonn, Inst Inorgan Chem, Dept Xray Crystallog, D-53121 Bonn, Germany

[4] Helmholtz Ctr Infect Res, Dept Biol Chem, D-38124 Braunschweig, Germany

[5] Univ Bonn, Inst Pharmaceut, D-53121 Bonn, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 10期

关键词：

PENICILLIUM-HERQUEI; DEOXYHERQUEINONE; METABOLITES;

D O I：

10.1021/np2004227

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The marine endophytic fungus Coniothyrium cereale produces the structurally unusual polyketide-type alkaloids (-)-cereolactam (1) and (-)-cereoaldomine (3), incorporating a lactam and an imine functionality, respectively, as well as the related metabolite (-)-trypethelone (2). Compounds 1 and 3 showed selective inhibition of human leukocyte elastase with IC(50) values of 9.28 and 3.01 mu M, respectively. Compound 2 was found to be inhibitory toward Mycobacterium phlei, Staphylococcus aureus, and Escherichia coli and also cytotoxic against mouse fibroblast cells (IC(50) = 7.5 mu M).

引用

页码：2282 / 2285

页数：4

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