The Role of Progesterone Receptors in Breast Cancer

被引：140
作者：
Li, Zhuo [1 ]
Wei, Hongrui [1 ]
Li, Siyan [1 ]
Wu, Pei [2 ]
Mao, Xiaoyun [1 ]
机构：
[1] China Med Univ, Affiliated Hosp 1, Dept Breast Surg, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Dept Surg Oncol, Shenyang, Liaoning, Peoples R China
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2022年 / 16卷
基金：
中国国家自然科学基金;
关键词：
progesterone receptor; breast cancer; endocrine therapy; SEX STEROID-HORMONES; N-TERMINAL REGION; ESTROGEN-RECEPTOR; DNA-BINDING; SIGNALING PATHWAYS; HUMAN-PREGNANCY; MICE LACKING; CROSS-TALK; EXPRESSION; TUMOR;
D O I：
10.2147/DDDT.S336643
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The progesterone receptor (PR) modulates estrogen receptors alpha (ER alpha) action in breast cancer; it is an upregulated target gene of ER, and its expression is dependent on estrogen. PR is also a valuable prognostic biomarker in breast cancer, especially in hormone-positive breast cancer. High expression of PR is more frequently observed in tumors with a better baseline prognosis (ie, luminal A) than tumors with a poor baseline prognosis (ie, luminal B). In the following review, we present the role of PR in breast cancer, including the genomic characteristics and pathways in breast cancer, PR and endocrine therapy.
引用
收藏
页码：305 / 314
页数：10
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