In Situ Generation of Copper Nanoparticles by Rongalite and Their Use as Catalyst for Click Chemistry in Water

被引：19

作者：

Poshala, Soumya ^{[1
]}

Thunga, Sanjeeva ^{[1
]}

Manchala, Saikumar ^{[1
]}

Kokatla, Hari Prasad ^{[1
]}

机构：

[1] Natl Inst Technol Warangal, Dept Chem, Warangal 506004, Telangana, India

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 48期

关键词：

Click Reaction; CuNPs; In situ; Rongalite; Triazoles; 1,3-DIPOLAR CYCLOADDITION; TERMINAL ALKYNES; FUNCTIONALIZED 1,2,3-TRIAZOLES; HUISGEN CYCLOADDITION; BENZOSULTINE-SULFONE; OXIDE NANOPARTICLES; GREEN REAGENT; AZIDES; EFFICIENT; DERIVATIVES;

D O I：

10.1002/slct.201802584

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel, efficient and green protocol for the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction by using copper nanoparticles (CuNPs), generated in situ by a green reducing agent, rongalite, is reported. Terminal alkynes reacted with benzyl, aryl and alkyl azides in the presence of copper nanoparticles and beta -cyclodextrin (beta-CD) in water. The reactions exclusively generated the corresponding regiospecific 1,4-disubstituted 1,2,3-triazoles in good to excellent yields. Notably, in situ generation of copper nanoparticles does not require any additional stabilizing agents or special reaction conditions. beta-cyclodextrin plays dual role as a stabilizing agent as well as phase transfer catalyst. This protocol is also applicable for gram scale reactions.

引用

页码：13759 / 13764

页数：6

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