Autoimmune and inflammatory responses in Kashin-Beck disease compared with rheumatoid arthritis and osteoarthritis

被引：17

作者：

Tian, Lifang ^{[1
,2
]}

Wang, Wei ^{[1
,2
]}

Hou, Weikun ^{[1
,2
]}

Tian, Juan ^{[1
,2
]}

Zhong, Nannan ^{[1
,2
]}

Sun, Jian ^{[1
,2
]}

Guo, Dawei ^{[3
]}

Yao, Jianfeng ^{[4
]}

Xu, Peng ^{[4
]}

Su, Peihe ^{[5
]}

He, Lan ^{[5
]}

Lu, Shemin ^{[1
,2
,6
]}

机构：

[1] Xi An Jiao Tong Univ, Coll Med, Dept Genet & Mol Biol, Xian 710061, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Coll Med, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China

[3] Shaanxi Prov Inst Endem Dis Control, Xian 710049, Shaanxi, Peoples R China

[4] Xian Red Cross Hosp, Dept Joint Surg, Xian 710054, Shaanxi, Peoples R China

[5] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Rheumatoid Immun Dis, Xian 710061, Shaanxi, Peoples R China

[6] Xi An Jiao Tong Univ, Coll Med, Dept Epidemiol & Hlth Stat, Xian 710061, Shaanxi, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2011年 / 72卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Kashin-Beck disease; Cartilage; Collagen; Autoimmunity; Inflammation; CYCLIC CITRULLINATED PEPTIDE; II COLLAGEN; CARTILAGE; ANTIBODIES; ONSET; IX; AUTOANTIBODIES; XI;

D O I：

10.1016/j.humimm.2011.05.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To examine plasma levels of arthritis-related autoantibodies and inflammatory factors in Kashin-Beck disease (KBD) patients compared with rheumatoid arthritis (RA) patients, osteoarthritis (OA) patients, and healthy controls, the plasma levels of autoantibodies to types II, IX, and XI collagen and cyclic citrullinated peptide (CCP) and immunoglobulin (Ig)-G and IgM rheumatoid factors (IgG-RF and IgM-RF) from 45 KBD patients, 39 RA patients, 46 OA patients, and 30 healthy controls were determined by enzyme-linked immunosorbent assay. The plasma concentrations of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) were measured using the Griess method and bioassay, respectively. Statistical analysis was performed using one-way analysis of variance followed by the least significant difference t test for differences among groups. Results indicated that the plasma levels of collagen IX antibodies, IgG-RF, and NO significantly increased in KBD patients compared with patients with RA and OA and the control group. The levels of collagen XI antibodies, CCP antibodies, and IgM-RF but not collagen II antibodies and TNF-alpha were significantly increased in the plasma of the KBD group compared with that of the control group. We conclude that autoimmunity and inflammation may be involved in the pathogenesis of KBD, in particular in the advanced stage. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：812 / 816

页数：5