Expedient Ytterbium Triflate Catalyzed One-Pot Mulicomponent Synthesis of Spiro[indoline-3,4′-pyrano [2,3-c]pyrazole]

被引：12

作者：

Muthuraja, Perumal ^{[1
]}

Prakash, Sengodu ^{[1
]}

Siva, Govindaraj ^{[2
]}

Muthusubramanian, Shanmugam ^{[3
]}

Manisankar, Paramasivam ^{[1
]}

机构：

[1] Alagappa Univ, Dept Chem, Karaikkudi 630006, Tamil Nadu, India

[2] Syngene Int Ltd, Dept Synthet Organ Chem, Biocon Pk, Bengaluru 60099, Karnataka, India

[3] Madurai Kamaraj Univ, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 31期

关键词：

Atom-economy; Green synthesis; Lewis acid catalyst; Multicomponent synthesis; Spiro-indole; SMALL-MOLECULE INHIBITORS; 1,3-DIPOLAR CYCLOADDITION REACTION; STRUCTURE-BASED DESIGN; MDM2-P53; INTERACTION; REGIOSELECTIVE SYNTHESIS; CONVENIENT SYNTHESIS; EFFICIENT SYNTHESIS; SPIRO-OXINDOLES; AMINO-ACIDS; DERIVATIVES;

D O I：

10.1002/slct.201701261

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have synthesized a set of multi-substituted spiro[indoline-, 4'-pyrano[2, 3-c] pyrazole] from 5-chloroisatin, substituted phenyl hydrazines, 2-chloroacetonitrile/2-bromoacetonitrile/2hydroxy-1,4-naphthaquionone and ethyl acetoacetate in the presence of ytterbium triflate as catalyst in one-pot four component method at room temperature. The synthesized compounds are confirmed by FT-IR, 1D and 2DNMR spectroscopic techniques. Green synthetic methodology is adopted for the using green solvent ethanol, low temperature and easy work up which resulted in higher atom economy.

引用

页码：10071 / 10075

页数：5