Health-related quality of life in patients receiving oral anti-coagulants: a cross-sectional study

被引：8
作者：
Sridharan, Kannan [1 ]
Al Banny, Rashed [2 ]
Qader, Ali Mohamed [3 ]
Husain, Aysha [2 ,4 ]
Qader, Kawther Mohamed [5 ]
机构：
[1] Arabian Gulf Univ, Coll Med & Med Sci, Dept Pharmacol & Therapeut, Manama, Bahrain
[2] Minist Hlth, Dept Cardiol, Salmaniya Med Complex, Manama, Bahrain
[3] Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain
[4] RCSI Bahrain, Manama, Bahrain
[5] Minist Hlth, Salmaniya Med Complex, Manama, Bahrain
来源：
EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2020年 / 18卷 / 05期
关键词：
Warfarin; dabigatran; quality of life; atrial fibrillation; NONVALVULAR ATRIAL-FIBRILLATION; VITAMIN-K ANTAGONISTS; ANTICOAGULATION THERAPY; ADHERENCE; WARFARIN; SATISFACTION; DABIGATRAN; MANAGEMENT; STROKE; IMPACT;
D O I：
10.1080/14779072.2020.1760092
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: Patients receiving long-term anticoagulants were reported with varied health-related quality of life (HrQoL). We assessed HrQoL in patients receiving either warfarin or dabigatran from a tertiary care hospital. Methods: A cross-sectional study was carried out following consent from patients on oral anticoagulants. Demographics, prothrombin time international normalized ratio (PT-INR), and drug-related details were collected. A validated Arabic version of the perception of anticoagulant treatment questionnaire (PACT-2) was used to assess HrQoL under three dimensions: convenience; burden of disease; and treatment satisfaction. Results: One-hundred and fifty patients were recruited. Overall good quality of life was observed as indicated by the average score of 80.3 in the warfarin group and, moderate in the dabigatran (average score of 68). Highly adherent and elderly patients receiving warfarin were significantly more likely to have good quality of life. Therapeutic PT-INR and high medication adherence were the primary domains significantly associated with good quality of life amongst patients with warfarin. Conclusion: We observed good quality of life in patients receiving warfarin particularly those in the categories of elderly, with therapeutic PT-INR and high medication adherence. Small sample size with dabigatran precludes any firm conclusions.
引用
收藏
页码：309 / 314
页数：6
相关论文
共 33 条
[1]   New Oral Anticoagulants vs Vitamin K Antagonists: Benefits for Health-Related Quality of Life in Patients with Atrial Fibrillation [J].
Alegret, Josep M. ;
Vinolas, Xavier ;
Arias, Miguel A. ;
Martinez-Rubio, Antoni ;
Rebollo, Pablo ;
Rafols, Carles ;
Martinez-Sande, Jose L. .
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2014, 11 (07) :680-684
[2]   Values and preferences for oral antithrombotic therapy in patients with atrial fibrillation: physician and patient perspectives [J].
Alonso-Coello, Pablo ;
Montori, Victor M. ;
Diaz, M. Gloria ;
Devereaux, Philip J. ;
Mas, Gemma ;
Diez, Ana I. ;
Sola, Ivan ;
Roura, Merce ;
Souto, Juan C. ;
Oliver, Sven ;
Ruiz, Rafael ;
Coll-Vinent, Blanca ;
Gich, Ignasi ;
Schuenemann, Holger J. ;
Guyatt, Gordon .
HEALTH EXPECTATIONS, 2015, 18 (06) :2318-2327
[3]   Values and Preferences of Physicians and Patients With Nonvalvular Atrial Fibrillation Who Receive Oral Anticoagulation Therapy for Stroke Prevention [J].
Andrade, Jason G. ;
Krahn, Andrew D. ;
Skanes, Allan C. ;
Purdham, Daniel ;
Ciaccia, Antonio ;
Connors, Sean .
CANADIAN JOURNAL OF CARDIOLOGY, 2016, 32 (06) :747-753
[4]  
Andujar- Mateos P., 2015, J DENT ORAL HEALTH, V1, P1
[5]   Comparison of health-related quality of life among patients using novel oral anticoagulants or warfarin for non-valvular atrial fibrillation [J].
Balci, Kevser Gulcihan ;
Balci, Mustafa Mucahit ;
Canpolat, Ugur ;
Sen, Fatih ;
Akboga, Mehmet K. ;
Suleymanoglu, Muhammed ;
Kuyumcu, Serdar ;
Maden, Orhan ;
Selcuk, Hatice ;
Selcuk, Mehmet Timur .
ANATOLIAN JOURNAL OF CARDIOLOGY, 2016, 16 (07) :474-481
[6]   National Trends in Ambulatory Oral Anticoagulant Use [J].
Barnes, Geoffrey D. ;
Lucas, Eleanor ;
Alexander, G. Caleb ;
Goldberger, Zachary D. .
AMERICAN JOURNAL OF MEDICINE, 2015, 128 (12) :1300-+
[7]   Real-life experience of quality of life, treatment satisfaction, and adherence in patients receiving oral anticoagulants for atrial fibrillation [J].
Benzimra, Michael ;
Bonnamour, Beatrix ;
Duracinsky, Martin ;
Lalanne, Christophe ;
Aubert, Jean-Pierre ;
Chassany, Olivier ;
Aubin-Auger, Isabelle ;
Mahe, Isabelle .
PATIENT PREFERENCE AND ADHERENCE, 2018, 12 :79-87
[8]   The Quality of Life Scale (QOLS): Reliability, validity, and utilization [J].
Carol S Burckhardt ;
Kathryn L Anderson .
Health and Quality of Life Outcomes, 1 (1)
[9]   Direct oral anticoagulants versus warfarin: is new always better than the old? [J].
Burn, John ;
Pirmohamed, Munir .
OPEN HEART, 2018, 5 (01)
[10]  
Cosansu K, 2019, HERZ, V44, P743, DOI 10.1007/s00059-019-4828-1
1234