Aloe vera or Resveratrol Supplementation in Larval Diet Delays Adult Aging in the Fruit Fly, Drosophila melanogaster

被引：51

作者：

Chandrashekara, Kagepura Thammaiah ^{[1
]}

Shakarad, Mallikarjun N. ^{[1
]}

机构：

[1] Univ Delhi, Dept Zool, Delhi 110007, India

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2011年 / 66卷 / 09期

关键词：

Antioxidant enzymes; Neuroprotection; Fruit fly; Resveratrol; Aloe vera; LIFE-SPAN; RESTRICTION; SELECTION; EVOLUTION; NEUROTOXICITY; REPRODUCTION; ACTIVATION; NUTRITION; PROTECTS; SIRTUINS;

D O I：

10.1093/gerona/glr103

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Longevity extension in Drosophila melanogaster by feeding diet supplemented with chemicals throughout adulthood can cause harmful side effects. We tested the effect of larval diet supplementation with five different concentrations of resveratrol and one concentration of Aloe vera extract on the adult longevity of short-lived D melanogaster populations. Resveratrol and A vera extract supplementation of larval diet extended adult longevity in both the male and female flies without reducing fecundity but by efficient reactive oxygen species scavenging through increased antioxidant enzymes activity and better neuroprotection as indicated by increased locomotor activity in adult males.

引用

页码：965 / 971

页数：7

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