Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

被引：31

作者：

Desrivieres, Sylvane ^{[1
]}

Lourdusamy, Anbarasu ^{[1
]}

Mueller, Christian ^{[1
]}

Ducci, Francesca ^{[1
]}

Wong, Cybele P. ^{[1
]}

Kaakinen, Marika ^{[2
,3
]}

Pouta, Anneli ^{[6
]}

Hartikainen, Anna-Liisa ^{[4
]}

Isohanni, Matti ^{[5
]}

Charoen, Pimphen ^{[7
]}

Peltonen, Leena ^{[8
]}

Freimer, Nelson

Elliott, Paul ^{[7
]}

Jarvelin, Marjo-Riitta

Schumann, Gunter ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, MRC SGDP Ctr, London SE5 8AF, England

[2] Univ Oulu, Inst Hlth Sci, Oulu, Finland

[3] Univ Oulu, Bioctr Oulu, Oulu, Finland

[4] Univ Oulu, Dept Clin Sci Obstet & Gynecol, Oulu, Finland

[5] Univ Oulu, Dept Clin Sci Psychiat, Oulu, Finland

[6] Natl Inst Hlth & Welf, Dept Lifecourse & Serv, Oulu, Finland

[7] Imperial Coll, Dept Epidemiol & Publ Hlth, London, England

[8] Univ Helsinki, Inst Mol Med FIMM, FIN-00014 Helsinki, Finland

来源：

ADDICTION BIOLOGY | 2011年 / 16卷 / 03期

基金：

芬兰科学院; 英国惠康基金; 英国医学研究理事会;

关键词：

Addiction; adolescent; alcohol; glucocorticoid receptor; NR3C1; polymorphism; ASSOCIATION; POPULATION; DISORDERS; AGE;

D O I：

10.1111/j.1369-1600.2010.00239.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P(adj) = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.

引用

页码：510 / 513

页数：4

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