No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease

被引：3

作者：

Friedrich, P. ^{[2
]}

Feulner, T. M. ^{[1
,2
]}

Laws, S. M. ^{[2
,3
]}

Eckart, K. ^{[2
]}

Perneczky, R. ^{[2
]}

Kurz, A. ^{[4
]}

Foerstl, H. ^{[4
]}

Riemenschneider, M. ^{[1
,2
,4
]}

机构：

[1] Univ Saarland, Dept Psychiat & Psychotherapy, D-66421 Homburg, Saar, Germany

[2] Tech Univ Munich, Dept Psychiat & Psychotherapy, Lab Neurochem & Neurogenet, Munich, Germany

[3] Edith Cowan Univ, Sch Exercise Biomed & Hlth Sci, Sir James McCusker Alzheimers Dis Res Unit, Ctr Excellence Alzheimers Dis Res & Care, Joondalup, WA 6027, Australia

[4] Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 03期

关键词：

Alzheimer's disease; Genetics; Tachykinin receptor; TACR2; CHROMOSOME-10; LOCUS;

D O I：

10.1016/j.neurobiolaging.2009.03.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The Tachykinin Receptor 2 (TACR2) located at chromosome 10q21.3 belongs to a class of receptors that bind members of the tachykinin neurotransmitter family. The TACR2 binds neurokinin A, also known as substance K, and is expressed in distinct parts of the human brain. Functionally, the TACR2 has been implicated in stress induced hippocampal acetylcholine release and the gene TACR2 is located within a previously identified linkage region for Alzheimer's disease (AD) on chromosome 10q21. Together, both facts make the TACR2 a reasonable positional and functional candidate gene for AD. Genotyping of 13 single nucleotide polymorphisms (SNPs) covering the entire gene and haplotypic analysis revealed no association with AD. Thus, we conclude that TACR2 can be excluded as a major susceptibility gene conferring risk to AD. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：544 / 545

页数：2

共 7 条

[1] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[2] Control by tachykinin NK2 receptors of CRF1 receptor-mediated activation of hippocampal acetylcholine release in the rat and guinea-pig [J].

Desvignes, C ;

Rouquier, L ;

Souilhac, J ;

Mons, G ;

Rodier, D ;

Soubrié, P ;

Steinberg, R .

NEUROPEPTIDES, 2003, 37 (02) :89-97

[3] Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees [J].

Ertekin-Taner, N ;

Graff-Radford, N ;

Younkin, LH ;

Eckman, C ;

Baker, M ;

Adamson, J ;

Ronald, J ;

Blangero, J ;

Hutton, M ;

Younkin, SG .

SCIENCE, 2000, 290 (5500) :2303-+

[4] The structure of haplotype blocks in the human genome [J].

Gabriel, SB ;

Schaffner, SF ;

Nguyen, H ;

Moore, JM ;

Roy, J ;

Blumenstiel, B ;

Higgins, J ;

DeFelice, M ;

Lochner, A ;

Faggart, M ;

Liu-Cordero, SN ;

Rotimi, C ;

Adeyemo, A ;

Cooper, R ;

Ward, R ;

Lander, ES ;

Daly, MJ ;

Altshuler, D .

SCIENCE, 2002, 296 (5576) :2225-2229

[5] Neurokinins robustly activate the majority of septohippocampal cholinergic neurons [J].

Morozova, Elena ;

Wu, Min ;

Dumalska, Iryna ;

Alreja, Meenakshi .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 27 (01) :114-122

[6] Susceptibility locus for Alzheimer's disease on chromosome 10 [J].

Myers, A ;

Holmans, P ;

Marshall, H ;

Kwon, J ;

Meyer, D ;

Ramic, D ;

Shears, S ;

Booth, J ;

DeVrieze, FW ;

Crook, R ;

Hamshere, M ;

Abraham, R ;

Tunstall, N ;

Rice, F ;

Carty, S ;

Lillystone, S ;

Kehoe, P ;

Rudrasingham, V ;

Jones, L ;

Lovestone, S ;

Perez-Tur, J ;

Williams, J ;

Owen, MJ ;

Hardy, J ;

Goate, AM .

SCIENCE, 2000, 290 (5500) :2304-+

[7] ASSOCIATION OF APOLIPOPROTEIN-E ALLELE EPSILON-4 WITH LATE-ONSET FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE [J].

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, D ;

GEORGEHYSLOP, PHS ;

PERICAKVANCE, MA ;

JOO, SH ;

ROSI, BL ;

GUSELLA, JF ;

CRAPPERMACLACHLAN, DR ;

ALBERTS, MJ ;

HULETTE, C ;

CRAIN, B ;

GOLDGABER, D ;

ROSES, AD .

NEUROLOGY, 1993, 43 (08) :1467-1472

← 1 →