Persisting autoimmune heparin-induced thrombocytopenia after elective abdominal aortic aneurysm repair: a case report

被引：6

作者：

Roberge, Guillaume ^{[1
,2
]}

Tritschler, Tobias ^{[1
,3
]}

MacGillivray, Caleb ^{[4
]}

Dufresne, Laurence ^{[5
]}

Nagpal, Sudhir Kumar ^{[5
]}

Scarvelis, Dimitrios ^{[1
]}

机构：

[1] Univ Ottawa, Ottawa Hosp, Dept Med, Res Inst, Ottawa, ON, Canada

[2] Univ Laval, Ctr Hosp Univ Quebec, Dept Gen Internal Med, Hop St Francois dAssise, Quebec City, PQ, Canada

[3] Univ Bern, Bern Univ Hosp, Dept Gen Internal Med, Inselspital, Bern, Switzerland

[4] Univ Ottawa, Ottawa Hosp, Clin Epidemiol Program, Thrombosis Res Grp, Ottawa, ON, Canada

[5] Univ Ottawa, Ottawa Hosp, Div Vasc Surg, Ottawa, ON, Canada

来源：

JOURNAL OF THROMBOSIS AND THROMBOLYSIS | 2020年 / 50卷 / 03期

基金：

瑞士国家科学基金会; 加拿大健康研究院;

关键词：

Case report; Heparin; Thrombocytopenia; Thrombosis; Immunoglobulin; INTRAVENOUS IMMUNOGLOBULIN; LABORATORY DIAGNOSIS; PLATELET ACTIVATION; HIT; THERAPY; RISK;

D O I：

10.1007/s11239-020-02062-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Persisting heparin-induced thrombocytopenia (HIT) is characterized by ongoing thrombocytopenia more than 7 days after stopping heparin. It is part of cases referred to as autoimmune HIT (aHIT). In contrast to typical HIT cases, aHIT involves heparin-independent platelet activation mechanism highlighted by a strongly positive functional assay done without heparin. We report the first case of persisting HIT after an elective abdominal aortic aneurysm repair presenting with arterial and venous thrombosis, and describe the potential role of intravenous immunoglobulin in such patients.

引用

页码：674 / 677

页数：4

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