The effect of erythropoietin on endometrial edema during ischemia-reperfusion injury in rats

被引：0

作者：

Tsompos, Constantinos ^{[1
]}

Panoulis, Constantinos ^{[2
]}

Toutouzas, Konstantinos ^{[3
]}

Zografos, George ^{[3
]}

Papalois, Apostolos ^{[4
]}

机构：

[1] Mesologi Cty Hosp, Dept Obstet & Gynecol, Etoloakarnania, Greece

[2] Univ Athens, Aretaie Hosp, Dept Obstet & Gynecol, Athens, Greece

[3] Univ Athens, Ippokrate Gen Hosp, Dept Surg, Athens, Greece

[4] ELPEN Pharmaceut Co Inc SA, Expt Res Ctr, Athens, Greece

来源：

JOURNAL OF HISTOTECHNOLOGY | 2016年 / 39卷 / 03期

关键词：

Endometrial edema; Erythropoietin; Ischemia; Reperfusion; LONG-TERM TREATMENT; ISCHEMIA/REPERFUSION INJURY; MODEL;

D O I：

10.1080/01478885.2016.1202406

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This experimental study examined the effect of erythropoietin (Epo) in a rat model and particularly in an ischemia-reperfusion protocol. The potential beneficial effect of Epo was studied pathologically using endometrial edema (EE) lesions. Endometrial edema was evaluated 60 min after reperfusion (Groups A and C) and 120 min after reperfusion (Groups B and D) in rats. Epo was administered only in Groups C and D. Epo administration non-significantly increased the EE scores by 0.05 (p = 0.9315). Reperfusion non-significantly increased the EE scores by 0.15 (p = 0.6508). Epo administration and reperfusion together non-significantly increased the EE scores by 0.027 (p = 0.8898). Epo administration, reperfusion, and their interaction reduced the EE scores from significant to non-significant levels. Perhaps a study time longer than 2 h or a higher Epo dose could result in complete resolution of the endometrial edema formed as a result of the ischemia-reperfusion injury in this rat model.

引用

页码：97 / 101

页数：5

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