piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells

被引：230
作者：
Cheng, Jia [1 ]
Deng, Hongxia [1 ]
Xiao, Bingxiu [1 ]
Zhou, Hui [1 ]
Zhou, Fei [1 ]
Shen, Zhisen [1 ,2 ]
Guo, Junming [1 ]
机构：
[1] Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Univ, Sch Med, Affiliated Lihuili Hosp, Ningbo 315040, Zhejiang, Peoples R China
来源：
CANCER LETTERS | 2012年 / 315卷 / 01期
基金：
中国国家自然科学基金;
关键词：
PiRNA; Non-coding RNA; Carcinogenesis; Gastric cancer; HIWI GENE; EXPRESSION; MICRORNA; PIWI; MECHANISM; CARCINOMA; PIRNAS; RISK;
D O I：
10.1016/j.canlet.2011.10.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：12 / 17
页数：6
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