Toxoplasma gondii seropositivity is negatively associated with multiple sclerosis

被引：24

作者：

Stascheit, Frauke ^{[1
]}

Paul, Friedemann ^{[1
,2
,3
]}

Harms, Lutz ^{[1
]}

Rosche, Berk ^{[1
]}

机构：

[1] Charite, Dept Neurol & Expt Neurol, Berlin, Germany

[2] Charite, NeuroCure Clin Res Ctr, Berlin, Germany

[3] Charite, Dept Neurol, Clin & Expt Multiple Sclerosis Res Ctr, Berlin, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 285卷

关键词：

Multiple sclerosis; Case-control studies; Parasitic infections; Hygiene hypothesis; Toxoplasma gondii; ENVIRONMENTAL RISK-FACTORS; CIGARETTE-SMOKING; ANTIBODIES; INFECTION;

D O I：

10.1016/j.jneuroim.2015.05.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Toxoplasma (T.) gondii is a ubiquitous intracellular parasitic protozoan that was recently associated with various autoimmune diseases. Objectives: We aimed to investigate the prevalence of T. gondii IgG and IgM antibodies between MS patients and healthy controls. Methods: Sera from 163 MS, 91 clinically isolated syndrome cases and 178 age and gender matched controls were evaluated for the prevalence of T. gondii IgG antibodies utilizing chemiluminescent immunoassay (ARCHITECT). Results: MS-patients showed a significantly lower prevalence for T. gondii IgG antibodies compared to controls (333% vs. 47.9%; p = 0.011, OR = 1.8 (95% CI 12-3.2)). Conclusion: The results demonstrate a negative association between an infection with the parasite T. gondii and the presence of MS. (C) 2015 Published by Elsevier B.V.

引用

页码：119 / 124

页数：6

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