Solid-phase three-component domino reactions: Combinatorial approach to substituted 3,4-dihydro-2H-pyrans

被引：0

作者：

Tietze, LF

Hippe, T

Steinmetz, A

机构：

来源：

SYNLETT | 1996年 / 11期

关键词：

solid-phase synthesis; combinatorial chemistry; dihydropyrans; Knoevenagel reaction; Hetero-Diels-Alder reaction; multicomponent reaction; domino reaction;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Resin-linked acetoacetate 1 reacts with aldehydes 2 to give the Knoevenagel products 3, which undergo hetero-Diels-Alder-reactions with the enol ethers 4 to afford the polymer-bound cycloadducts 5/6. Cleavage from the support is achieved by base-induced transesterification to give the 3,4-dihydropyrans 7/8 in high purity. The suitability of these transformations for generating combinatorial libraries is demonstrated.

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页码：1043 / &

页数：3

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