The role of melatonin in parasite biology

被引：16

作者：

Bagnaresi, Piero ^{[1
]}

Nakabashi, Myna ^{[2
]}

Thomas, Andrew P. ^{[3
]}

Reiter, Russel J. ^{[4
]}

Garcia, Celia R. S. ^{[2
]}

机构：

[1] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, Brazil

[3] UMDNJ, New Jersey Med Sch, Dept Physiol & Pharmacol, Newark, NJ USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2012年 / 181卷 / 01期

关键词：

Malaria; Melatonin; Circadian rhythm; Plasmodium falciparum; Plasmodium chabaudi; Calcium signaling; LIZARDS AMEIVA-AMEIVA; RED-BLOOD-CELLS; PLASMODIUM-FALCIPARUM; MALARIA PARASITE; TRYPANOSOMA-CRUZI; EXPERIMENTAL-INFECTION; SIGNAL-TRANSDUCTION; TOXOPLASMA-GONDII; GAMMA-INTERFERON; CA2+ RELEASE;

D O I：

10.1016/j.molbiopara.2011.09.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regarded as the circadian hormone in mammals, melatonin is a highly conserved molecule, present in nearly all species. In this review, we discuss the role of this indolamine and its precursors in the cell biology of parasites and the role of the molecule in the physiology of the host. In Plasmodium, melatonin can modulate intracellular concentrations of calcium and CAMP, which in turn can regulate kinase activity and cell cycle. In Trypanosoma infections, modulation of the immune system by melatonin is extremely important in controlling the parasite population. Melatonin also contributes to the inflammatory response to Toxoplasma gondii infection. Thus, there are a number of unique adaptations involving intricate connections between melatonin and the biology of the parasite-host relationship. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 59 条

[51] Generation of the melatonin endocrine message in mammals: A review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters [J].