The role of melatonin in parasite biology

被引：16
作者：
Bagnaresi, Piero [1 ]
Nakabashi, Myna [2 ]
Thomas, Andrew P. [3 ]
Reiter, Russel J. [4 ]
Garcia, Celia R. S. [2 ]
机构：
[1] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil
[2] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, Brazil
[3] UMDNJ, New Jersey Med Sch, Dept Physiol & Pharmacol, Newark, NJ USA
[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2012年 / 181卷 / 01期
关键词：
Malaria; Melatonin; Circadian rhythm; Plasmodium falciparum; Plasmodium chabaudi; Calcium signaling; LIZARDS AMEIVA-AMEIVA; RED-BLOOD-CELLS; PLASMODIUM-FALCIPARUM; MALARIA PARASITE; TRYPANOSOMA-CRUZI; EXPERIMENTAL-INFECTION; SIGNAL-TRANSDUCTION; TOXOPLASMA-GONDII; GAMMA-INTERFERON; CA2+ RELEASE;
D O I：
10.1016/j.molbiopara.2011.09.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regarded as the circadian hormone in mammals, melatonin is a highly conserved molecule, present in nearly all species. In this review, we discuss the role of this indolamine and its precursors in the cell biology of parasites and the role of the molecule in the physiology of the host. In Plasmodium, melatonin can modulate intracellular concentrations of calcium and CAMP, which in turn can regulate kinase activity and cell cycle. In Trypanosoma infections, modulation of the immune system by melatonin is extremely important in controlling the parasite population. Melatonin also contributes to the inflammatory response to Toxoplasma gondii infection. Thus, there are a number of unique adaptations involving intricate connections between melatonin and the biology of the parasite-host relationship. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 6
页数：6
相关论文
共 59 条
  • [1] Calcium regulation in the intraerythrocytic malaria parasite Plasmodium falciparum
    Alleva, LM
    Kirk, K
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2001, 117 (02) : 121 - 128
  • [2] Alves E, 2011, J BIOL CHEM, V13, P1
  • [3] Bagnaresi P, 2008, OPEN PARASITOL J, V2, P4
  • [4] Bagnaresi P, 2009, INT J GEN MED, V2, P47
  • [5] Pinealectomy and melatonin administration in rats: Their effects on plasma leptin levels and relationship with zinc
    Baltaci, A. K.
    Mogulkoc, R.
    [J]. ACTA BIOLOGICA HUNGARICA, 2007, 58 (04): : 335 - 343
  • [6] Benedetto N, 2000, MICROBIOLOGICA, V23, P167
  • [7] Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle
    Beraldo, FH
    Almeida, FM
    da Silva, AM
    Garcia, CRS
    [J]. JOURNAL OF CELL BIOLOGY, 2005, 170 (04) : 551 - 557
  • [8] Products of tryptophan catabolism induce Ca2+ release and modulate the cell cycle of Plasmodium falciparum malaria parasites
    Beraldo, FH
    Garcia, CRS
    [J]. JOURNAL OF PINEAL RESEARCH, 2005, 39 (03) : 224 - 230
  • [9] Red blood cells of the lizards Ameiva ameiva (Squamata, Teiidae) display multiple mechanisms to control cytosolic calcium
    Beraldo, FH
    Sartorello, R
    Gazarini, ML
    Caldeira, W
    Garcia, CRS
    [J]. CELL CALCIUM, 2002, 31 (02) : 79 - 87
  • [10] Signal transduction in red blood cells of the lizards Ameiva ameiva and Tupinambis merianae (Squamata, Teiidae)
    Beraldo, FH
    Sartorello, R
    Lanari, RD
    Garcia, CRS
    [J]. CELL CALCIUM, 2001, 29 (06) : 439 - 445
123456