Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury

被引：20

作者：

Bao, Hai-jun ^{[1
]}

Qiu, Hai-yang ^{[1
]}

Kuai, Jin-xia ^{[2
]}

Song, Cheng-jie ^{[3
]}

Wang, Shao-xian ^{[1
]}

Wang, Chao-qun ^{[1
]}

Peng, Hua-bin ^{[1
]}

Han, Wen-can ^{[1
]}

Wu, Yong-ping ^{[1
]}

机构：

[1] Xuzhou Med Coll, Dept Pathol, Xuzhou, Jiangsu, Peoples R China

[2] Xuzhou Med Coll, Dept Forens Med, Xuzhou, Jiangsu, Peoples R China

[3] Xuzhou Med Coll, Dept Physiol, Xuzhou, Jiangsu, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2016年 / 11卷 / 07期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; apoptosis; apelin-13; traumatic brain injury; brain edema; blood-brain barrier; brain water content; aquaporin-4; caspase-3; neural regeneration; CELL-DEATH; MODEL; AQUAPORIN-4; EDEMA; APJ; PROTECTS; RECEPTOR; AUTOPHAGY; LIGAND; GENE;

D O I：

10.4103/1673-5374.187049

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The adipocytokine, apelin-13, is an abundantly expressed peptide in the nervous system. Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy. However, secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear. Here, we found that apelin-13 significantly decreases cerebral water content, mitigates blood-brain barrier destruction, reduces aquaporin-4 expression, diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus, and reduces apoptosis. These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect.

引用

页码：1128 / 1133

页数：6

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