LncSpA: LncRNA Spatial Atlas of Expression across Normal and Cancer Tissues

被引:45
|
作者
Lv, Dezhong [1 ]
Xu, Kang [1 ]
Jin, Xiyun [1 ]
Li, Junyi [1 ]
Shi, Yuchen [1 ]
Zhang, Mengying [1 ]
Jin, Xiaoyan [1 ]
Li, Yongsheng [1 ,2 ,3 ]
Xu, Juan [1 ,2 ,3 ]
Li, Xia [1 ,2 ,3 ]
机构
[1] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China
[2] Hainan Med Univ, Key Lab Trop Translat Med, Minist Educ, Haikou, Peoples R China
[3] Hainan Med Univ, Coll Biomed Informat & Engn, Haikou, Hainan, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
LONG NONCODING RNAS; GENE;
D O I
10.1158/0008-5472.CAN-19-2687
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Long noncoding RNAs (lncRNA) play important roles in maintaining morphology and function of tissues, and their regulatory effectiveness is closely associated with spatial expression. To provide a comprehensive spatial atlas of expression for lncRNA, we propose LncSpA (http://bio-bigdata.hrbmu.edu.cn/LncSpA) to explore tissue-elevated (TE) lncRNA across human normal and adult and pediatric cancer tissues. In total, 71,131 and 12,007 TE lncRNAs and 634 clinical-related TE lncRNAs were identified across 38 normal and 33 adult cancer tissues. Moreover, 4,688 TE and 413 clinicalrelated lncRNAs were identified in pediatric cancer. By quick searching or query options, users can obtain eight major types of detailed information for lncRNA via various visualization techniques, including qualitative and quantitative spatial expression in different resources, coexpressed mRNAs, predicted function, known disease association, and the potential to serve as diagnostic or prognostic markers. LncSpA will be a valuable resource to understand lncRNA functions across tissues and cancers, leading to enhanced therapeutic strategies in precision oncology. Significance: LncSpA is a new interactive resource that provides the spatial expression pattern of lncRNA across thousands of normal and cancer samples representing major tissue types.
引用
收藏
页码:2067 / 2071
页数:5
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