Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions

被引：69

作者：

Anstead, Clare A. ^{[1
]}

Korhonen, Pasi K. ^{[1
]}

Young, Neil D. ^{[1
]}

Hall, Ross S. ^{[1
]}

Jex, Aaron R. ^{[1
]}

Murali, Shwetha C. ^{[2
]}

Hughes, Daniel S. T. ^{[2
]}

Lee, Siu F. ^{[3
]}

Perry, Trent ^{[3
]}

Stroehlein, Andreas J. ^{[1
,4
]}

Ansell, Brendan R. E. ^{[1
]}

Breugelmans, Bert ^{[1
]}

Hofmann, Andreas

Qu, Jiaxin ^{[2
]}

Dugan, Shannon ^{[2
]}

Lee, Sandra L. ^{[2
]}

Chao, Hsu ^{[2
]}

Dinh, Huyen ^{[2
]}

Han, Yi ^{[2
]}

Doddapaneni, Harsha V. ^{[2
]}

Worley, Kim C. ^{[2
]}

Muzny, Donna M. ^{[2
]}

Ioannidis, Panagiotis ^{[5
,6
]}

Waterhouse, Robert M. ^{[5
,6
]}

Zdobnov, Evgeny M. ^{[5
,6
]}

James, Peter J. ^{[7
]}

Bagnall, Neil H. ^{[8
]}

Kotze, Andrew C. ^{[8
]}

Gibbs, Richard A. ^{[2
]}

Richards, Stephen ^{[2
]}

Batterham, Philip ^{[3
]}

Gasser, Robin B. ^{[1
]}

机构：

[1] Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic 3010, Australia

[2] Baylor Coll Med, Dept Human & Mol Genet, Houston, TX 77030 USA

[3] Univ Melbourne, Sch Biosci, Parkville, Vic 3010, Australia

[4] Griffith Univ, Eskitis Inst Drug Discovery, Struct Chem Program, Brisbane, Qld 4111, Australia

[5] Univ Geneva, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

[6] Swiss Inst Bioinformat, CH-1211 Geneva, Switzerland

[7] Univ Queensland, Queensland Biosci Precinct, QAAFI, Ecosci Precinct, Brisbane, Qld 4072, Australia

[8] CSIRO, Queensland Biosci Precinct, Agr Flagship, Brisbane, Qld 4067, Australia

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

基金：

澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会; 加拿大自然科学与工程研究理事会; 瑞士国家科学基金会;

关键词：

DROSOPHILA-MELANOGASTER; INSECT IMMUNITY; BLOWFLY STRIKE; GENE FAMILY; PROTEIN; SHEEP; EXPRESSION; LARVAE; RESISTANCE; RECEPTORS;

D O I：

10.1038/ncomms8344

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lucilia cuprina is a parasitic fly of major economic importance worldwide. Larvae of this fly invade their animal host, feed on tissues and excretions and progressively cause severe skin disease (myiasis). Here we report the sequence and annotation of the 458-megabase draft genome of Lucilia cuprina. Analyses of this genome and the 14,544 predicted protein-encoding genes provide unique insights into the fly's molecular biology, interactions with the host animal and insecticide resistance. These insights have broad implications for designing new methods for the prevention and control of myiasis.

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