Mitochondrial DNA Copy Number: Linking Diabetes and Cancer

被引：10

作者：

Memon, Ashfaque A. A. ^{[1
,2
]}

Vats, Sakshi ^{[1
]}

Sundquist, Jan ^{[1
]}

Li, Yanni ^{[1
]}

Sundquist, Kristina ^{[1
]}

机构：

[1] Lund Univ Reg Skane, Ctr Primary Hlth Care Res, Malmo, Sweden

[2] Lund Univ Reg Skane, Skane Univ Hosp, Ctr Primary Hlth Care Res, Wallenberg Lab, 6th Floor,Inga Marie Nilssons Gata 53, S-20502 Malmo, Sweden

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2022年 / 37卷 / 16期

关键词：

mitochondrial copy number; mitochondrial dysfunction; biomarker; diabetes; cancer; PERIPHERAL-BLOOD LEUKOCYTES; TRANSCRIPTION FACTOR-A; SKELETAL-MUSCLE; BREAST-CANCER; COLORECTAL-CANCER; PANCREATIC-CANCER; DOUBLE-BLIND; MOLECULAR-MECHANISMS; OXIDATIVE STRESS; POOR-PROGNOSIS;

D O I：

10.1089/ars.2022.0100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent Advances: Various studies have suggested that mitochondrial DNA copy number (mtDNA-CN), a surrogate biomarker of mitochondrial dysfunction, is an easily quantifiable biomarker for chronic diseases, including diabetes and cancer. However, current knowledge is limited, and the results are controversial. This has been attributed mainly to methodology and study design.Critical Issues: The incidence of diabetes and cancer has increased significantly in recent years. Moreover, type 2 diabetes (T2D) has been shown to be a risk factor for cancer. mtDNA-CN has been associated with both T2D and cancer. However, it is not known whether mtDNA-CN plays any role in the association between T2D and cancer.Significance: In this review, we have discussed mtDNA-CN in diabetes and cancer, and reviewed the literature and methodology used in published studies so far. Based on the literature review, we have speculated how mtDNA-CN may act as a link between diabetes and cancer. Furthermore, we have provided some recommendations for reliable translation of mtDNA-CN as a biomarker.Future Directions: Further research is required to elucidate the role of mtDNA-CN in the association between T2D and cancer. If established, early lifestyle interventions, such as physical activity and diet control that improve mitochondrial function, may help preventing cancer in patients with T2D.

引用

页码：1168 / 1190

页数：23

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