H2S Donors and Their Use in Medicinal Chemistry

被引：49

作者：

Magli, Elisa ^{[1
]}

Perissutti, Elisa ^{[1
]}

Santagada, Vincenzo ^{[1
]}

Caliendo, Giuseppe ^{[1
]}

Corvino, Angela ^{[1
]}

Esposito, Gianluca ^{[1
]}

Esposito, Giovanna ^{[1
]}

Fiorino, Ferdinando ^{[1
]}

Migliaccio, Marco ^{[1
]}

Scognamiglio, Antonia ^{[1
]}

Severino, Beatrice ^{[1
]}

Sparaco, Rosa ^{[1
]}

Frecentese, Francesco ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Sch Med, Via D Montesano 49, I-80131 Naples, Italy

来源：

BIOMOLECULES | 2021年 / 11卷 / 12期

关键词：

hydrogen sulfide; natural H2S donors; synthetic H2S donors; H2S release; medicinal chemistry; HYDROGEN-SULFIDE DONOR; LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION; CYSTATHIONINE BETA-SYNTHASE; MAST-CELL DEGRANULATION; ANIMATION-LIKE STATE; NITRIC-OXIDE; IN-VITRO; SIGNALING MOLECULE; FLUORESCENT-PROBES; PARKINSONS-DISEASE;

D O I：

10.3390/biom11121899

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H2S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H2S levels has a potential therapeutic value. Consequently, synthetic H2S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H2S donors; furthermore, herein we discuss their preparation, the H2S-releasing mechanisms, and their -biological applications.

引用

页数：51

共 50 条

[1] The biology of H2S: What can we learn from the use of H2S donors?
Moore, Philip K.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2015, 47 : S5 - S5
[2] A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications
Powell, Chadwick R.
Dillon, Kearsley M.
Matson, John B.
BIOCHEMICAL PHARMACOLOGY, 2018, 149 : 110 - 123
[3] H2S donors with optical responses
Pluth, Michael D.
Zhao, Yu
Cerda, Matthew M.
CHEMICAL TOOLS FOR IMAGING, MANIPULATING, AND TRACKING BIOLOGICAL SYSTEMS: DIVERSE CHEMICAL, OPTICAL AND BIOORTHOGONAL METHODS, 2020, 641 : 149 - 164
[4] On mechanism of isothiocyanates as H2S donors
Lin, Yi
Yang, Xin
Huang, Dejian
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
[5] Development of new H2S donors
Zhao, Yu
Stein, Jason
Park, Chung-Min
Baez, Nelmi O. Devarie
Xian, Ming
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2012, 27 : S30 - S30
[6] All H2S donors are not created equal
Papapetropoulos, A.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2015, 47 : S8 - S8
[7] Nucleoside phosphorothioates as the new H2S donors
Beltowski, Jerzy
Guranowski, Andrzej
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2013, 31 : S35 - S36
[8] Investigating the Use of Mitochondria-Targeted H2S Donors for the Treatment of NSCLC
Pickles, Sophie
Donovan, Chantal
Chimankar, Vrushali
Sahu, Priyanka
Malyla, Vamshikrishna
Tu, Xiaofan
Gomez, Henry
Budden, Kurtis
Dua, Kamal
Rahman, Atiqur
Whiteman, Matthew
Hansbro, Philip M.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2019, 15 : 39 - 40
[9] Organelle-Targeted H2S Probes Enable Visualization of the Subcellular Distribution of H2S Donors
Montoya, Leticia A.
Pluth, Michael D.
ANALYTICAL CHEMISTRY, 2016, 88 (11) : 5769 - 5774
[10] Applications of Synthetic Organic Tetrasulfides as H2S Donors
Cerda, Matthew M.
Hammers, Matthew D.
Earp, Mary S.
Zakharov, Lev N.
Pluth, Michael D.
ORGANIC LETTERS, 2017, 19 (09) : 2314 - 2317

← 1 2 3 4 5 →