Understanding and Harnessing Epithelial-Mesenchymal Interactions in the Development of Palmoplantar Identity

被引：7

作者：

Tsai, Jerry ^{[1
]}

Rostom, Mary ^{[1
]}

Garza, Luis A. ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Dept Dermatol, Canc Res Bldg 2,Room 204,1550 Orleans St, Baltimore, MD 21287 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2022年 / 142卷 / 02期

基金：

美国国家卫生研究院;

关键词：

SKIN;

D O I：

10.1016/j.jid.2021.06.016

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte-fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites.

引用

收藏

页码：282 / 284

页数：3

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