Electrode kinetics and ternary complex formation of Cd2+-anti biotics-vitam in-B5 system.: A polarographic study

Cd2+ complexes with antibiotics viz. neomycin, chlortetracycline, oxytetracycline, tetracycline, penicillin-V and penicillin-G as primary ligands and vitamin-B-5 as secondary ligand have been reported at pH = 7.30 +/- 0.01 and mu = 1.0 M KNO3 at 298 K by polarographic technique.(1) Cd2+ formed 1:1:1, 1:1:2, and 1:2:1 complexes with a stability constants trend of neomycin < chlortetracycline < oxytetracycline < tetracycline < penicillin-V < penicillin-G can be explained on the basis of the nature of ligands, bonding, and steric hindrance of these drugs. The nature of electrode processes were reversible and diffusion controlled. The values of stability constants showed that these drugs can be used to reduce the toxicity of Cd.