Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII

被引：90

作者：

Oh, MC ^{[1
]}

Derkach, VA ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 07期

关键词：

D O I：

10.1038/nn1476

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GluR1 and GluR2 subunits compose AMPA receptors (AMPARs) in the mature hippocampus, and both the GluR1 subunit and Ca2+/calmodulin-dependent protein kinase II (CaMKII) are required for synaptic plasticity, memory and learning. Although GluR1 phosphorylation by CaMKII is preserved, the functional regulation of AMPARs by phosphorylation is lost in the presence of the GluR2 subunit. Our findings define a previously unknown, dominant role of the GluR2 subunit in signaling mediated by CaMKII at AMPARs.

引用

页码：853 / 854

页数：2

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