INFLUENCE OF TYPE 2 DIABETES ON THE ANTHROPOMETRIC INDICES, BODY COMPOSITION AND MICRONUTRIENT STATUS OF PATIENTS SUBMITTED TO LAPAROSCOPIC SLEEVE GASTRECTOMY

被引:2
作者
Ciobarca, Daniela [1 ]
Catoi, Adriana Florinela [2 ]
Copaescu, Catalin [3 ]
Pop, Ioana Delia [4 ]
Miere, Doina [1 ]
Crisan, Gianina [5 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Bromatol Hyg Nutr, Cluj Napoca 400337, Romania
[2] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Physiopathol, Cluj Napoca 400012, Romania
[3] GT Popa Univ Med & Pharm, Iasi, Romania
[4] Univ Agr Sci & Vet Med, Dept Exact Sci, Cluj Napoca 400372, Romania
[5] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Bot, Cluj Napoca 400337, Romania
关键词
type; 2; diabetes; laparoscopic sleeve gastrectomy; body composition; micronutrient status; WEIGHT-LOSS; DEFICIENCY; METFORMIN;
D O I
10.31925/farmacia.2022.4.13
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The objectives of this study were to determine whether or not the presence type 2 diabetes (T2D) is associated with significantly less postoperative weight loss and to evaluate the impact of T2D on body composition and micronutrient status in patients submitted to laparoscopic sleeve gastrectomy (LSG). The study was conducted on 50 men and women (12 with T2D) that were evaluated preoperatively and at 6 and 12 months following LSG. Patients with T2D lost significantly less weight and visceral fat at 12 months following LSG compared with their counterparts without T2D, despite comparable BMI at baseline. Also, patients with T2D exhibited a significantly higher fat-free mass at the end of the follow-up period (but also lost less weight), although the total fat mass loss did not differ significantly between patients with and without T2D both pre- and postoperatively. 25(OH) D deficiency was present in all patients in baseline and this abnormality persisted throughout the follow-up period, irrespective of T2D status and routine nutritional supplementation; vitamin B12 serum levels were significantly higher (but keeping within the normal range) in the T2D group pre- and post-LSG. T2D negatively impacts both weight loss and body composition improvement following LSG. Except for vitamin B12, micronutrient levels evaluated herein were comparable between the two groups.
引用
收藏
页码:671 / 682
页数:12
相关论文
共 42 条
[1]  
American Diabetes Association, 2018, Clin Diabetes, V36, P14, DOI 10.2337/cd17-0119
[2]   Standardized outcomes reporting in metabolic and bariatric surgery [J].
Brethauer, Stacy A. ;
Kim, Julie ;
el Chaar, Maher ;
Papasavas, Pavlos ;
Eisenberg, Dan ;
Rogers, Ann ;
Ballem, Naveen ;
Kligman, Mark ;
Kothari, Shanu .
SURGERY FOR OBESITY AND RELATED DISEASES, 2015, 11 (03) :489-506
[3]   Long-Term Effects of Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Body Composition and Bone Mass Density [J].
Buhler, Julian ;
Rast, Silvan ;
Beglinger, Christoph ;
Peterli, Ralph ;
Peters, Thomas ;
Gebhart, Martina ;
Meyer-Gerspach, Anne Christin ;
Wolnerhanssen, Bettina Karin .
OBESITY FACTS, 2021, 14 (01) :131-140
[4]   Muscle and adipose tissue morphology, insulin sensitivity and beta-cell function in diabetic and nondiabetic obese patients: effects of bariatric surgery [J].
Camastra, Stefania ;
Vitali, Alessandra ;
Anselmino, Marco ;
Gastaldelli, Amalia ;
Bellini, Rosario ;
Berta, Rossana ;
Severi, Ilenia ;
Baldi, Simona ;
Astiarraga, Brenno ;
Barbatelli, Giorgio ;
Cinti, Saverio ;
Ferrannini, Ele .
SCIENTIFIC REPORTS, 2017, 7
[5]   Factors associated with weight loss after gastric bypass [J].
Campos, Guilherme M. ;
Rabl, Charlotte ;
Mulligan, Kathleen ;
Posselt, Andrew ;
Rogers, Stanley J. ;
Westphalen, Antonio C. ;
Lin, Feng ;
Vittinghoff, Eric .
ARCHIVES OF SURGERY, 2008, 143 (09) :877-883
[6]   Does diabetes affect weight loss after gastric bypass? [J].
Carbonell, Alfredo M. ;
Wolfe, Luke G. ;
Meador, Jill G. ;
Sugerman, Harvey J. ;
Kellum, John M. ;
Maher, Jarnes W. .
SURGERY FOR OBESITY AND RELATED DISEASES, 2008, 4 (03) :441-444
[7]   Bariatric surgery-induced weight loss in patients with and without type 2 diabetes mellitus [J].
Carvalho, Thatiany A. ;
Ronsoni, Marcelo F. ;
Hohl, Alexandre ;
van de Sande-Lee, Simone .
CLINICAL OBESITY, 2020, 10 (02)
[8]   Predictive Value of Gut Peptides in T2D Remission: Randomized Controlled Trial Comparing Metabolic Gastric Bypass, Sleeve Gastrectomy and Greater Curvature Plication [J].
Casajoana, Anna ;
Pujol, Jordi ;
Garcia, Amador ;
Elvira, Jordi ;
Virgili, Nuria ;
Javier de Oca, Francisco ;
Duran, Xavier ;
Fernandez-Veledo, Sonia ;
Vendrell, Joan ;
Vilarrasa, Nuria .
OBESITY SURGERY, 2017, 27 (09) :2235-2245
[9]   Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status [J].
Ciobarca, Daniela ;
Catoi, Adriana Florinela ;
Copaescu, Catalin ;
Miere, Doina ;
Crisan, Gianina .
NUTRIENTS, 2020, 12 (01)
[10]  
Ciobarca Daniela Muresan, 2022, Med Pharm Rep, V95, P24, DOI 10.15386/mpr-2094