Never resting region - mPFC in schizophrenia

被引：11

作者：

Bleich-Cohen, Maya ^{[1
]}

Kupchik, Marina ^{[3
,4
]}

Gruberger, Michal ^{[2
]}

Kotler, Moshe ^{[3
,4
]}

Hendler, Talma ^{[2
,3
]}

机构：

[1] Tel Aviv Sourasky Med Ctr, Funct Brain Ctr, Funct Brain Imaging Unit, Wohl Inst Adv Imaging, IL-64239 Tel Aviv, Israel

[2] Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[4] Beer Yaakov Mental Hlth Ctr, Ness Ziona, Israel

来源：

SCHIZOPHRENIA RESEARCH | 2012年 / 140卷 / 1-3期

关键词：

Language; fMRI; DMN; Schizophrenia; FUNCTIONAL CONNECTIVITY; CORPUS-CALLOSUM; DEFAULT MODE; FAILURE; BRAIN;

D O I：

10.1016/j.schres.2012.06.030

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Reduced functional connectivity (FC) in schizophrenia has been demonstrated either in task related or 'default network' areas, but not between these networks, which interact meaningfully. We examined the role of FC between the inferior frontal gyrus (IFG) and medial prefrontal cortex (mPFC) in determining language-lateralization during a language task, and its association with structural integrity of the corpus-callosum. Only schizophrenia patients presented increased mPFC-IFG FC during task, which additionally corresponded to decreased white-matter organization of the corpus-callosum. These findings suggest that inability to suppress irrelevant internally-generated information while processing external stimuli might be the basis of functional psychopathology in schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：155 / 158

页数：4

共 18 条

[1] Diminished language lateralization in schizophrenia corresponds to impaired inter-hemispheric functional connectivity [J].

Bleich-Cohen, Maya ;

Sharon, Haggai ;

Weizman, Ronit ;

Poyurovsky, Michael ;

Faragian, Sarit ;

Hendler, Talma .

SCHIZOPHRENIA RESEARCH, 2012, 134 (2-3) :131-136

[2] Diminished Neural Sensitivity to Irregular Facial Expression in First-Episode Schizophrenia [J].

Bleich-Cohen, Maya ;

Strous, Rael D. ;

Even, Raz ;

Rotshtein, Pia ;

Yovel, Galit ;

Iancu, Iulian ;

Olmer, Ahikam ;

Hendler, Talma .

HUMAN BRAIN MAPPING, 2009, 30 (08) :2606-2616

[3] Reduced language lateralization in first-episode schizophrenia: An fMRI index of functional asymmetry [J].

Bleich-Cohen, Maya ;

Hendler, Talma ;

Kotler, Moshe ;

Strous, Rael D. .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2009, 171 (02) :82-93

[4] The brain's default network - Anatomy, function, and relevance to disease [J].

Buckner, Randy L. ;

Andrews-Hanna, Jessica R. ;

Schacter, Daniel L. .

YEAR IN COGNITIVE NEUROSCIENCE 2008, 2008, 1124 :1-38

[5] The human brain is intrinsically organized into dynamic, anticorrelated functional networks [J].

Fox, MD ;

Snyder, AZ ;

Vincent, JL ;

Corbetta, M ;

Van Essen, DC ;

Raichle, ME .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (27) :9673-9678

[6] FUNCTIONAL CONNECTIVITY - THE PRINCIPAL-COMPONENT ANALYSIS OF LARGE (PET) DATA SETS [J].

FRISTON, KJ ;

FRITH, CD ;

LIDDLE, PF ;

FRACKOWIAK, RSJ .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (01) :5-14

[7] Towards a neuroscience of mind-wandering [J].

Gruberger, Michal ;

Ben-Simon, Eti ;

Levkovitz, Yechiel ;

Zangen, Abraham ;

Hendler, Talma .

FRONTIERS IN HUMAN NEUROSCIENCE, 2011, 5

[8] First-episode psychosis is characterized by failure of deactivation but not by hypo- or hyperfrontality [J].

Guerrero-Pedraza, A. ;

McKenna, P. J. ;

Gomar, J. J. ;

Sarro, S. ;

Salvador, R. ;

Amann, B. ;

Carrion, M. I. ;

Landin-Romero, R. ;

Blanch, J. ;

Pomarol-Clotet, E. .

PSYCHOLOGICAL MEDICINE, 2012, 42 (01) :73-84

[9] Interhemispheric hypoconnectivity in schizophrenia: Fiber integrity and volume differences of the corpus callosum in patients and unaffected relatives [J].

Knoeche, Christian ;

Oertel-Knoechel, Viola ;

Schoenmeyer, Ralf ;

Rotarska-Jagiela, Anna ;

van de Ven, Vincent ;

Prvulovic, David ;

Haenschel, Corinna ;

Uhlhaas, Peter ;

Pantel, Johannes ;

Hampel, Harald ;

Linden, David E. J. .

NEUROIMAGE, 2012, 59 (02) :926-934

[10] Failure to deactivate in the prefrontal cortex in schizophrenia:: dysfunction of the default mode network? [J].

Pomarol-Clotet, E. ;

Salvador, R. ;

Sarro, S. ;

Gomar, J. ;

Vila, F. ;

Martinez, A. ;

Guerrero, A. ;

Ortiz-Gil, J. ;

Sans-Sansa, B. ;

Capdevila, A. ;

Cebamanos, J. M. ;

McKenna, P. J. .

PSYCHOLOGICAL MEDICINE, 2008, 38 (08) :1185-1193

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