Anticancer Activity of 2-Amino-substituted-1,4-naphthoquinone Derivatives in Ovarian Cancer Cells

被引：7

作者：

Shin, Sujeong ^{[1
]}

Lee, Haneul ^{[1
]}

Jeon, Cheolmin ^{[1
]}

Preya, Umma Hafsa ^{[2
,3
]}

Choi, Jung-Hye ^{[2
,3
]}

Park, Jeong Ho ^{[1
]}

机构：

[1] Hanbat Natl Univ, Dept Chem & Biol Engn, Daejeon 34158, South Korea

[2] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 02447, South Korea

[3] Kyung Hee Univ, Coll Pharm, Seoul 02447, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2017年 / 38卷 / 12期

关键词：

2-Amino-substituted-1; 4-naphthoquinone derivatives; Anticancer activity; Ovarian cancer cells; BIOLOGICAL EVALUATION; SUBSTITUTED 1,4-NAPHTHOQUINONES; ANTIBACTERIAL AGENTS; ANTIFUNGAL; DESIGN; NAPHTHOQUINONES;

D O I：

10.1002/bkcs.11315

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Amino-substituted-1,4-naphthoquinone derivatives (10-17) were synthesized from coupling reaction between 1,4-dihydroxynaphthalene and amines in the presence of catalyst CeCl(3)(.)7H(2)O. Their anticancer activity was evaluated by using three ovarian cancer cells (A2780, SKOV3, and OVCAR3). Among the eight compounds, compound 13 containing metal chelating moiety had a relatively potent cytotoxic activity (IC50 < 10 M) on all three ovarian cancer cells.

引用

页码：1411 / 1414

页数：4

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