Sulphadiazine-induced obstructive renal failure complicating treatment of HIV-associated toxoplasmosis

被引：5

作者：

Allinson, J.

Topping, W. ^{[2
]}

Edwards, S. G.

Miller, R. F. ^{[1
]}

机构：

[1] UCL, Mortimer Market Ctr, Res Dept Infect & Publ Hlth, Div Populat Hlth, London WC1E 6JB, England

[2] Univ Coll London Hosp Fdn Trust, Dept Imaging, London, England

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2012年 / 23卷 / 03期

关键词：

HIV; sulphadiazine; toxicity; sulpha drugs; renal failure; crystalluria; toxoplasmosis; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; PARENTERAL ANTIBIOTIC-THERAPY; INDUCED CRYSTALLURIA; AIDS PATIENTS; PATIENT; ENCEPHALITIS;

D O I：

10.1258/ijsa.2009.009539

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A patient with newly-diagnosed HIV infection and biopsy-proven cerebral toxoplasmosis was treated with sulphadiazine and pyrimethamine. Despite adequate hydration and daily examination of urine for sulphadiazine crystals obstructive uropathy due to bilateral ureteric stones with hydronephrosis occurred, resulting in rapid onset renal failure. Sulphadiazine was discontinued and clindamycin was substituted. With intravenous fluid hydration and bilateral nephrostomies the urolithiasis resolved. This case serves to remind clinicians of the need for vigilance when treating cerebral toxoplasmosis with sulphadiazine, in order to avoid this potentially serious complication of treatment.

引用

页码：210 / 212

页数：3

共 16 条

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