A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population

Liu S, Liu Y, Yin Y, Zhang X, Ma X. A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population. Objective: Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population. Methods: We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test. Results: No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls (?2 = 2.12, df = 2, P = 0.35 by genotype; ?2 = 0.005, df = 1, P = 0.94 by allele). Conclusions: Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.