Maxillary sinus augmentation with microstructured tricalcium phosphate ceramic in sheep

被引：5
作者：
Klijn, R. J. [1 ]
Hoekstra, J. W. M. [1 ]
Van Den Beucken, J. J. J. P. [1 ]
Meijer, G. J. [1 ,2 ]
Jansen, J. A. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Biomat, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Implantol & Periodontol, NL-6500 HB Nijmegen, Netherlands
来源：
CLINICAL ORAL IMPLANTS RESEARCH | 2012年 / 23卷 / 03期
关键词：
biomaterials; bone substitutes; tricalcium phosphate; maxillary sinus augmentation; AUTOGENOUS BONE-GRAFTS; DONOR SITE MORBIDITY; PLATELET-RICH PLASMA; FLOOR AUGMENTATION; ILIAC CREST; DENTAL IMPLANTS; HISTOMORPHOMETRIC EVALUATION; BOVINE HYDROXYAPATITE; ALVEOLAR CLEFTS; SURVIVAL RATES;
D O I：
10.1111/j.1600-0501.2011.02190.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective: The objective of this study was to evaluate the biological performance of osteoinductive microstructured tricalcium phosphate (MSTCP) particles in maxillary sinus floor augmentation surgery in sheep. Material and methods: Sinus floor augmentation was performed in eight Swifter sheep. In each animal, the maxillary sinus floor was unilaterally augmented with MSTCP particles. Computed tomography (CT) imaging and histological analyses were performed after 12 weeks of implantation. Results: Maxillofacial CT, histology, histomorphometrical analysis and sequential polychrome fluorescent labeling indicated that MSTCP particles provided a scaffold for cell ingrowth and bone formation. After a 12-week implantation period, the sinuses grafted with MSTCP showed an increased bone height of 6 mm and a mean total bone volume of 43%, with significant degradation of MSTCP particles. Conclusion: MSTCP particles represent a suitable bone substitute material for maxillary sinus floor augmentation surgery.
引用
收藏
页码：274 / 280
页数：7
相关论文
共 52 条
[41]  
Szabó G, 2001, INT J ORAL MAX IMPL, V16, P681
[42]  
Tong DC, 1998, INT J ORAL MAX IMPL, V13, P175
[43]  
Wallace Stephen S, 2003, Ann Periodontol, V8, P328, DOI 10.1902/annals.2003.8.1.328
[44]   Systematic evaluation of a tissue-engineered bone for maxillary sinus augmentation in large animal canine model [J].
Wang, Shaoyi ;
Zhang, Zhiyuan ;
Xia, Lunguo ;
Zhao, Jun ;
Sun, Xiaojuan ;
Zhang, Xiuli ;
Ye, Dongxia ;
Uludag, Hasan ;
Jiang, Xinquan .
BONE, 2010, 46 (01) :91-100
[45]   HETEROTOPIC BONE FORMED IN A SYNTHETIC SPONGE IN SKIN OF YOUNG PIGS [J].
WINTER, GD ;
SIMPSON, BT .
NATURE, 1969, 223 (5201) :88-&
[46]  
Yuan H., 2008, EUR CELLS MAT S2, V16, P14
[47]   Bone formation induced by calcium phosphate ceramics in soft tissue of dogs:: a comparative study between porous α-TCP and β-TCP [J].
Yuan, HP ;
De Bruijn, JD ;
Li, YB ;
Feng, JQ ;
Yang, ZJ ;
De Groot, K ;
Zhang, XD .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2001, 12 (01) :7-13
[48]   Material-dependent bone induction by calcium phosphate ceramics: a 2.5-year study in dog [J].
Yuan, HP ;
Yang, ZJ ;
de Bruijn, JD ;
de Groot, K ;
Zhang, XD .
BIOMATERIALS, 2001, 22 (19) :2617-2623
[49]   Osteoinductive ceramics as a synthetic alternative to autologous bone grafting [J].
Yuan, Huipin ;
Fernandes, Hugo ;
Habibovic, Pamela ;
de Boer, Jan ;
Barradas, Ana M. C. ;
de Ruiter, Ad ;
Walsh, William R. ;
van Blitterswijk, Clemens A. ;
de Bruijn, Joost D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (31) :13614-13619
[50]   Histomorphometry of human sinus floor augmentation using a porous β-tricalcium phosphate:: a prospective study [J].
Zerbo, IR ;
Zijderveld, SA ;
de Boer, A ;
Bronckers, ALJJ ;
de Lange, G ;
ten Bruggenkate, CM ;
Burger, EH .
CLINICAL ORAL IMPLANTS RESEARCH, 2004, 15 (06) :724-732
123456