Identification of liguzinediol metabolites in rats by ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

被引：19

作者：

Shan, Chen-xiao ^{[1
]}

Li, Wei ^{[1
]}

Wen, Hong-mei ^{[1
]}

Wang, Xin-zhi ^{[1
]}

Zhu, Yi-hang ^{[1
]}

Cui, Xiao-bing ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210029, Jiangsu, Peoples R China

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2012年 / 62卷

基金：

中国国家自然科学基金;

关键词：

Liguzinediol; UPLC/QTOF MS; Metabolites; Metabolic pathway; Rats;

D O I：

10.1016/j.jpba.2011.12.016

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF MS) was employed to investigate the in vivo metabolism of liguzinediol, Urine, bile, feces and plasma samples were collected after intravenous administration of 10 mg/kg liguzinediol to healthy rats. Alto-gether seven metabolites were detected and tentatively identified based on the characteristics of their protonated ions. The metabolites were mainly transformed by four main metabolic pathways including oxidation, sulfation, glycine conjugation and glucuronidation. Published by Elsevier B.V.

引用

页码：187 / 190

页数：4

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