Enantioselective hydrogenation of arecaidine over cinchona alkaloid-modified palladium catalyst:: A novel route to enantioenriched nipecotic acid derivatives

被引：16

作者：

Szollosi, Gyoergy ^{[1
]}

Szori, Kornel ^{[1
]}

Bartok, Mihaly ^{[1
,2
]}

机构：

[1] Univ Szeged, Hungarian Acad Sci, Stereochem Res Grp, H-6720 Szeged, Hungary

[2] Univ Szeged, Dept Organ Chem, H-6720 Szeged, Hungary

来源：

JOURNAL OF CATALYSIS | 2008年 / 256卷 / 02期

基金：

匈牙利科学研究基金会;

关键词：

hydrogenation; enantioselective; cinchona alkaloid; palladium catalyst; nipecotic acid; N-heterocyclic; carboxylic acids;

D O I：

10.1016/j.jcat.2008.04.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The hydrogenation of N-methyl-3,4-dehydronipecotic acid (arecaidine) over Pd/Al2O3 catalyst in presence of cinchona alkaloids and benzylamine additive results in the quantitative formation of N-methylnipecotic acid in good (up to 60%) optical purity. The reaction is a novel example of the efficient use of chirally modified heterogeneous metal catalysts allowing the preparation of enantioenriched N-heterocyclic carboxylic acids. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：349 / 352

页数：4

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