Asymmetric Synthesis of Sulfinamides Using (-)-Quinine as Chiral Auxiliary

被引：25

作者：

Zhang, Yongda ^{[1
]}

Chitale, Sampada ^{[1
]}

Goyal, Navneet ^{[1
]}

Li, Guisheng ^{[1
]}

Han, Zhengxu S. ^{[1
]}

Shen, Sherry ^{[1
]}

Ma, Shengli ^{[1
]}

Grinberg, Nelu ^{[1
]}

Lee, Heewon ^{[1
]}

Lu, Bruce Z. ^{[1
]}

Senanayake, Chris H. ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 01期

关键词：

LIGANDS; ACID; SULFINIMINES; SULFOXIDES;

D O I：

10.1021/jo201825b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A process has been designed and demonstrated for the asymmetric synthesis of sulfinamides using quinine as auxiliary. A variety of chiral sulfinamides including N-alkyl sulfinamides with diverse structure were prepared in good yields and excellent enantioselectivity starting from easily available and inexpensive reagents. The auxiliary quinine could be recovered and recycled.

引用

页码：690 / 695

页数：6

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