Aberrant expression of the apoptosis-related proteins BAK and MCL1 in T cells in multiple sclerosis

被引：10

作者：

Mandel, Ilana ^{[3
]}

Paperna, Tamar ^{[3
]}

Miller, Ariel ^{[1
,2
,3
]}

机构：

[1] Carmel Hosp, Div Neuroimmunol, IL-34362 Haifa, Israel

[2] Carmel Hosp, Multiple Sclerosis Ctr, IL-34362 Haifa, Israel

[3] Technion Israel Inst Technol, Rappaport Fac Med & Res Inst, Carmel Med Ctr, Haifa, Israel

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 244卷 / 1-2期

关键词：

Apoptosis; Autoimmune; BAK; MCL1; Multiple sclerosis; Proteasome; INTERFERON-BETA THERAPY; BCL-2 FAMILY PROTEINS; DIAGNOSTIC-CRITERIA; DISEASE-ACTIVITY; B-LYMPHOCYTES; SURVIVAL; INHIBITOR; TRAIL; GLUCOCORTICOIDS; MAINTENANCE;

D O I：

10.1016/j.jneuroim.2011.12.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pathogenic T cells of multiple sclerosis (MS) patients have been suggested to be endowed with an increased resistance to apoptosis, contributing to their increased survival. We report herein increased levels of the antiapoptotic MCL1 protein and its half-life in activated lymphocytes of MS patients, which were not associated with differences in MCL1 RNA levels or with alterations in the expression levels of the known E3 ligases of MCL1-beta-TrCP and HUWE1. Concomitantly, the expression levels of the pro-apoptotic protein BAK were decreased in MS patients at relapse. These findings suggest the dysregulation of the apoptosis-related proteins MCL1 and BAK in MS. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：51 / 56

页数：6

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