The combined effects of telmisartan and ramipril on hypertension and cardiovascular injury

被引：5

作者：

Lee, Do-Hyung ^{[1
]}

Kim, Min-Tae ^{[1
]}

Lee, Hyung-Won ^{[1
]}

Han, Joo-Hui ^{[1
]}

Myung, Chang-Seon ^{[1
]}

机构：

[1] Chungnam Natl Univ, Dept Pharmacol, Coll Pharm, 99 Daehak Ro St, Daejeon 34134, South Korea

来源：

JOURNAL OF PHARMACEUTICAL INVESTIGATION | 2022年 / 52卷 / 04期

关键词：

Telmisartan; Ramipril; Combination therapy; Antihypertension; Cardiovascular protection; ANGIOTENSIN-ALDOSTERONE SYSTEM; BLOOD-PRESSURE; COMBINATION THERAPY; HIGH-RISK; MANAGEMENT; MORTALITY; LOSARTAN;

D O I：

10.1007/s40005-022-00567-x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose More than half of hypertensive patients receive combination therapy with two or more drugs. For combination therapy with antihypertensive drugs, it is recommended to use complementary drugs with different mechanisms. In this study, the effects of combination therapy with telmisartan (an angiotensin II receptor type 1 blocker) and ramipril (an angiotensin-converting enzyme inhibitor) on blood pressure control and cardiovascular protection were verified. Methods The systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate of spontaneously hypertensive rats (SHRs) were measured using a telemetry system. The protective effect of the drug combination against cardiovascular injury was determined by examining ligation-induced myocardial ischemia/reperfusion in SHRs and cuff-induced neointimal formation in C57BL/6 mice. Results The combination therapy with telmisartan and ramipril significantly decreased SBP and MAP. In addition, the combination therapy significantly increased the expression of endothelial nitric oxide synthase and inhibited the proliferation of vascular smooth muscle cells by inhibiting DNA synthesis at the cuff-induced vascular injury site. Conclusion The results of this study suggest that combination therapy with telmisartan and ramipril is an effective strategy for the treatment of hypertension and complications of hypertensive disorders.

引用

页码：443 / 451

页数：9

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