Evidence-Based Somatic Treatment of Depression in Adults

被引：7

作者：

Carlat, Daniel ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Dept Psychiat, Boston, MA 02111 USA

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2012年 / 35卷 / 01期

关键词：

Antidepressants; Selective serotonin reuptake inhibitors; Serotonin-norepinephrine reuptake inhibitors; Efficacy studies; STAR-D trial; STAR-ASTERISK-D; ANTIDEPRESSANTS; EFFICACY; METAANALYSIS; VENLAFAXINE; SEVERITY; BENEFITS; TRIALS;

D O I：

10.1016/j.psc.2011.11.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This article reviews recent studies and controversies about the effectiveness of antidepressant medications for depression. It is divided into three broad topics: (1) the heated controversy regarding how one should interpret "efficacy studies" of antidepressants, that is, the standard placebo-controlled double-blind studies used by drug companies to gain Food and Drug Administration approval; (2) "effectiveness studies," open-label studies enrolling types of patients who are excluded from efficacy studies, focusing on one enormous study in particular-the STAR-D trial; and (3) the evidence base that can guide clinicians in the choice of antidepressants for particular patients.

引用

页码：131 / +

页数：13

共 18 条

[1]

[Anonymous], 2004, COCHRANE DB SYST REV

[2] Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis [J].

Cipriani, Andrea ;

Furukawa, Toshiaki A. ;

Salanti, Georgia ;

Geddes, John R. ;

Higgins, Julian P. T. ;

Churchill, Rachel ;

Watanabe, Norio ;

Nakagawa, Atsuo ;

Omori, Ichiro M. ;

McGuire, Hugh ;

Tansella, Michele ;

Barbui, Corrado .

LANCET, 2009, 373 (9665) :746-758

[3] Antidepressant Drug Effects and Depression Severity A Patient-Level Meta-analysis [J].

Fournier, Jay C. ;

DeRubeis, Robert J. ;

Hollon, Steven D. ;

Dimidjian, Sona ;

Amsterdam, Jay D. ;

Shelton, Richard C. ;

Fawcett, Jan .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (01) :47-53

[4] Comparative Benefits and Harms of Second-Generation Antidepressants: Background Paper for the American College of Physicians [J].

Gartlehner, Gerald ;

Gaynes, Bradley N. ;

Hansen, Richard A. ;

Thieda, Patricia ;

DeVeaugh-Geiss, Angela ;

Krebs, Erin E. ;

Moore, Charity G. ;

Morgan, Laura ;

Lohr, Kathleen N. .

ANNALS OF INTERNAL MEDICINE, 2008, 149 (10) :734-U313

[5] What Did STAR*D Teach Us? Results From a Large-Scale, Practical, Clinical Trial for Patients With Depression [J].

Gaynes, Bradley N. ;

Warden, Diane ;

Trivedi, Madhukar H. ;

Wisniewski, Stephen R. ;

Fava, Maurizio ;

Rush, A. John .

PSYCHIATRIC SERVICES, 2009, 60 (11) :1439-1445

[6] A METAANALYSIS OF FLUOXETINE OUTCOME IN THE TREATMENT OF DEPRESSION [J].

GREENBERG, RP ;

BORNSTEIN, RF ;

ZBOROWSKI, MJ ;

FISHER, S ;

GREENBERG, MD .

JOURNAL OF NERVOUS AND MENTAL DISEASE, 1994, 182 (10) :547-551

[7]

Healy D, 2000, ANTIDEPRESSANT ERA, P91

[8]

Kirsch I., 2010, The emperor's new drugs: Exploding the antidepressant myth

[9] Initial severity and antidepressant benefits: A meta-analysis of data submitted to the food and drug administration [J].

Kirsch, Irving ;

Deacon, Brett J. ;

Huedo-Medina, Tania B. ;

Scoboria, Alan ;

Moore, Thomas J. ;

Johnson, Blair T. .

PLOS MEDICINE, 2008, 5 (02) :260-268

[10] Efficacy of Antidepressants for Dysthymia: A Meta-Analysis of Placebo-Controlled Randomized Trials [J].

Levkovitz, Yeciel ;

Tedeschini, Enrico ;

Papakostas, George I. .

JOURNAL OF CLINICAL PSYCHIATRY, 2011, 72 (04) :509-514

← 1 2 →