An engineered spider silk protein forms microspheres

被引：135

作者：

Slotta, Ute K. ^{[1
]}

Rammensee, Sebastian ^{[2
]}

Gorb, Stanislav ^{[3
]}

Scheibel, Thomas ^{[1
]}

机构：

[1] Tech Univ Munich, Lehrstuhl Biotechnol, Dept Chem, D-85747 Garching, Germany

[2] Tech Univ Munich, Lehrstuhl Biophys, Dept Phys, D-85747 Garching, Germany

[3] Max Planck Inst Met Res, Evolutionary Biomat Grp, D-70569 Stuttgart, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 24期

关键词：

biomaterials; Hofmeister effect; nanostructures; phase separation; self-assembly;

D O I：

10.1002/anie.200800683

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Fibrils or spheres? Spider silk proteins belong to the class of natively unfolded proteins. Depending on the experimental conditions, these proteins form nanofibrils or microspheres following two distinct aggregation pathways. A detailed model describes the assembly mechanism of spider silk proteins into microspheres. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4592 / 4594

页数：3

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