Effect of germanium-132 on low-density lipoprotein oxidation and atherosclerosis in Kurosawa and Kusanagi hypercholesterolemic rabbits

被引：11

作者：

Wakabayashi, Y ^{[1
]}

机构：

[1] Kitasato Univ, Sch Med, Dept Med, Sagamihara, Kanagawa 2288555, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 08期

关键词：

germanium-132 (Ge-132); antioxidant; low-density lipoprotein; atherosclerosis; Kurosawa and Kusanagi hypercholesterolemic (KHC) rabbits;

D O I：

10.1271/bbb.65.1893

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Germanium-132 (Ge-132) was given at 200 mg/kg of body weight to 8-week-old Kurosawa and Kusanagi hypercholesterolemic (KHC) rabbits. Thirty-six weeks later, the susceptibility of plasma low-density lipoprotein to oxidation and the morphology of atherosclerosis in the aorta and coronary artery were investigated. Treatment with Ge-132 resulted in decreases in the oxidation rate and in the formation rate of thiobarbituric acid-reactive substances following copper-induced oxidation of LDL. Ge-132 is suggested to possess antioxidative properties, but this did not lead to any attenuation of atherosclerotic progression in the KHC rabbits.

引用

页码：1893 / 1896

页数：4

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