Neurobiology of Pavlovian fear conditioning

被引：1334

作者：

Maren, S ^{[1
]}

机构：

[1] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2001年 / 24卷

关键词：

learning; memory; amygdala; hippocampus; synaptic plasticity;

D O I：

10.1146/annurev.neuro.24.1.897

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Learning the relationships between aversive events and the environmental stimuli that predict such events is essential to the survival of organisms throughout the animal kingdom. Pavlovian fear conditioning is an exemplar of this form of learning that is exhibited by both rats and humans. Recent years have seen an incredible surge in interest in the neurobiology of fear conditioning. Neural circuits underlying fear conditioning have been mapped, synaptic plasticity in these circuits has been identified, and biochemical and genetic manipulations are beginning to unravel the molecular machinery responsible for the storage of fear memories. These advances represent an important step in understanding the neural substrates of a rapidly acquired and adaptive form of associative learning and memory in mammals.

引用

页码：897 / 931

页数：35

共 241 条

[1] Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory [J].