Antibody responses to SARS-CoV-2 in patients with COVID-19

被引：5020

作者：

Long, Quan-Xin ^{[1
]}

Liu, Bai-Zhong ^{[2
]}

Deng, Hai-Jun ^{[1
]}

Wu, Gui-Cheng ^{[3
,4
]}

Deng, Kun ^{[5
]}

Chen, Yao-Kai ^{[6
]}

Liao, Pu ^{[7
]}

Qiu, Jing-Fu ^{[8
]}

Lin, Yong ^{[1
]}

Cai, Xue-Fei ^{[1
]}

Wang, De-Qiang ^{[1
]}

Hu, Yuan ^{[1
]}

Ren, Ji-Hua ^{[1
]}

Tang, Ni ^{[1
]}

Xu, Yin-Yin ^{[2
]}

Yu, Li-Hua ^{[2
]}

Mo, Zhan ^{[2
]}

Gong, Fang ^{[2
]}

Zhang, Xiao-Li ^{[2
]}

Tian, Wen-Guang ^{[2
]}

Hu, Li ^{[2
]}

Zhang, Xian-Xiang ^{[3
,4
]}

Xiang, Jiang-Lin ^{[3
,4
]}

Du, Hong-Xin ^{[3
,4
]}

Liu, Hua-Wen ^{[3
,4
]}

Lang, Chun-Hui ^{[3
,4
]}

Luo, Xiao-He ^{[3
,4
]}

Wu, Shao-Bo ^{[3
]}

Cui, Xiao-Ping ^{[3
,4
]}

Zhou, Zheng ^{[3
,4
]}

Zhu, Man-Man ^{[5
]}

Wang, Jing ^{[6
]}

Xue, Cheng-Jun ^{[6
]}

Li, Xiao-Feng ^{[6
]}

Wang, Li ^{[6
]}

Li, Zhi-Jie ^{[7
]}

Wang, Kun ^{[7
]}

Niu, Chang-Chun ^{[7
]}

Yang, Qing-Jun ^{[7
]}

Tang, Xiao-Jun ^{[8
]}

Zhang, Yong ^{[8
]}

Liu, Xia-Mao ^{[9
]}

Li, Jin-Jing ^{[9
]}

Zhang, De-Chun ^{[10
]}

Zhang, Fan ^{[10
]}

Liu, Ping ^{[11
]}

Yuan, Jun ^{[1
]}

Li, Qin ^{[12
]}

Hu, Jie-Li ^{[1
]}

Chen, Juan ^{[1
]}

机构：

[1] Chongqing Med Univ, Minist Educ, Key Lab Mol Biol Infect Dis, Chongqing, Peoples R China

[2] Chongqing Med Univ, Yongchuan Hosp Affiliated, Chongqing, Peoples R China

[3] Chongqing Univ, Three Gorges Hosp, Chongqing, Peoples R China

[4] Chongqing Three Gorges Cent Hosp, Chongqing, Peoples R China

[5] Chongqing Med Univ, Hosp Affiliated 3, Chongqing, Peoples R China

[6] Chongqing Publ Hlth Med Ctr, Div Infect Dis, Chongqing, Peoples R China

[7] Chongqing Peoples Hosp, Lab Dept, Chongqing, Peoples R China

[8] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China

[9] Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China

[10] Wanzhou Peoples Hosp, Chongqing, Peoples R China

[11] BioScience Co Ltd, Chongqing, Peoples R China

[12] Chongqing Ctr Dis Control & Prevent, Chongqing, Peoples R China

来源：

NATURE MEDICINE | 2020年 / 26卷 / 06期

基金：

美国国家科学基金会; 俄罗斯科学基金会;

关键词：

CORONAVIRUS;

D O I：

10.1038/s41591-020-0897-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections. A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.

引用

页码：845 / +

页数：13

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