Regulation of Chromatin Structure During Neural Development

被引：27

作者：

Kishi, Yusuke ^{[1
]}

Gotoh, Yukiko ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo, Japan

[2] Univ Tokyo, WPI, IRCN, Tokyo, Japan

来源：

FRONTIERS IN NEUROSCIENCE | 2018年 / 12卷

关键词：

neural development; chromatin; chromatin conformation capture (3C); topologically associated domain (TAD); A/B compartments; HISTONE METHYLTRANSFERASE ESET; NUCLEAR LAMINA INTERACTIONS; DE-LANGE-SYNDROME; PHASE-SEPARATION; 3D GENOME; TRANSCRIPTIONAL ACTIVATION; REVEALS PRINCIPLES; GENE-EXPRESSION; SAM DOMAIN; CTCF;

D O I：

10.3389/fnins.2018.00874

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The regulation of genome architecture is a key determinant of gene transcription patterns and neural development. Advances in methodologies based on chromatin conformation capture (3C) have shed light on the genome-wide organization of chromatin in developmental processes. Here, we review recent discoveries regarding the regulation of three-dimensional (3D) chromatin conformation, including promoterenhancer looping, and the dynamics of large chromatin domains such as topologically associated domains (TADs) and A/B compartments. We conclude with perspectives on how these conformational changes govern neural development and may go awry in disease states.

引用

页数：10

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