Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease

被引：77
作者：
Michelakakis, H
Spanou, C
Kondyli, A
Dimitriou, E
VanWeely, S
Hollak, CEM
VanOers, MHJ
Aerts, JMFG
机构：
[1] AGHIA SOPHIA CHILDRENS HOSP,DEPT IMMUNOL & HISTOCOMPATIBIL,ATHENS 11527,GREECE
[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT BIOCHEM & HEMATOL,NL-1105 AZ AMSTERDAM,NETHERLANDS
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1996年 / 1317卷 / 03期
关键词：
cytokine; TNF; Gaucher disease;
D O I：
10.1016/S0925-4439(96)00056-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease.
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收藏
页码：219 / 222
页数：4
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