Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease

被引：77

作者：

Michelakakis, H

Spanou, C

Kondyli, A

Dimitriou, E

VanWeely, S

Hollak, CEM

VanOers, MHJ

Aerts, JMFG

机构：

[1] AGHIA SOPHIA CHILDRENS HOSP,DEPT IMMUNOL & HISTOCOMPATIBIL,ATHENS 11527,GREECE

[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT BIOCHEM & HEMATOL,NL-1105 AZ AMSTERDAM,NETHERLANDS

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1996年 / 1317卷 / 03期

关键词：

cytokine; TNF; Gaucher disease;

D O I：

10.1016/S0925-4439(96)00056-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease.

引用

页码：219 / 222

页数：4

共 22 条

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