Dendriplex-Impregnated Hydrogels With Programmed Release Rate

被引：7
作者：
Apartsin, Evgeny [1 ,2 ,3 ,4 ]
Venyaminova, Alya [3 ]
Majoral, Jean-Pierre [1 ,2 ]
Caminade, Anne-Marie [1 ,2 ]
机构：
[1] CNRS, Lab Chim Coordinat, Toulouse, France
[2] Univ Toulouse, CNRS, LCC, Toulouse, France
[3] RAS, SB, Inst Chem Biol & Fundamental Med, Novosibirsk, Russia
[4] Novosibirsk State Univ, Novosibirsk, Russia
来源：
FRONTIERS IN CHEMISTRY | 2022年 / 9卷
基金：
欧盟地平线“2020”;
关键词：
dendrimers; oligonucleotides; hydrogel; polyelectrolyte complexes; controlled release; ANTICANCER SIRNA COCKTAILS; LOCAL-DELIVERY; PHOSPHORUS DENDRIMERS; AGAROSE GELS; IN-VITRO; DNA; CANCER; CELLS; ELECTROPHORESIS; SYSTEMS;
D O I：
10.3389/fchem.2021.780608
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA-dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.
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页数：7
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