TRIP13 is a predictor for poor prognosis and regulates cell proliferation, migration and invasion in prostate cancer

被引:34
作者
Dong, Liming [1 ]
Ding, Honglin [3 ]
Li, Yanpei [1 ]
Xue, Dongwei [1 ]
Li, Zhi [4 ]
Liu, Yili [1 ]
Zhang, Teng [2 ]
Zhou, Jian [2 ]
Wang, Ping [1 ]
机构
[1] China Med Univ, Dept Urol, Affiliated Hosp 4, 4 Chongshan Rd East, Shenyang 110000, Liaoning, Peoples R China
[2] China Med Univ, Dept Urol, Tachengqu Hosp, Tacheng 834700, Xinjiang, Peoples R China
[3] Chifeng Med Coll, Dept Urol, Affiliated Hosp, Chifeng 024000, Inner Mongolia, Peoples R China
[4] China Med Univ, Sch Pharmaeut Scineces, Dept Ethnpharmacol, Shenyang 110000, Liaoning, Peoples R China
关键词
TRIP13; Prostate cancer; Biomarker; Oncogene; EMT; STATISTICS; TUMOR; EXPRESSION; SIGNATURE; GENE;
D O I
10.1016/j.ijbiomac.2018.09.168
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Thyroid hormone receptor interactor 13 (TRIP13) has been reported to be overexpressed in serval types of human cancers, and regulate tumor cell proliferation, migration and invasion. However, the role of TRIP13 in prostate cancer was still unclear. In our study, the correlation between TRIP13 expression and clinical parameters including prognosis was evaluated in 160 prostate cancer patients. Moreover, the MIT assay, cell migration and invasion assays were performed to assess the effect of TRIP13 on prostate cancer cell biological behaviour. In our results, the expression status of TRIP13 was observed to be elevated in prostate cancer tissue samples through analyzing microarray (GSE55945). Furthermore, mRNA and protein TRIP13 expression were confirmed to be overexpressed in prostate cancer tissue samples and cell lines. High-expression of TRIP13 was correlated with present lymph node involvement, distant metastasis, high Gleason score, levels of serum PSA and poor prognosis in prostate cancer patients. The gain-of-function and loss-of-function studies suggested that TRIP13 functioned as oncogene to regulate prostate cancer cell proliferation, migration, invasion through controlling YWHAZ and epithelial-mesenchymal transition (EMT)-associated genes. In conclusion, TRIP13 is correlated with clinical progression and poor prognosis, and serves as oncogene in prostate cancer. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码:200 / 206
页数:7
相关论文
共 29 条
[1]  
[Anonymous], CHIN J CANC
[2]   A 19-Gene expression signature as a predictor of survival in colorectal cancer [J].
Aziz, Nurul Ainin Abdul ;
Mokhtar, Norfilza M. ;
Harun, Roslan ;
Mollah, Md Manir Hossain ;
Rose, Isa Mohamed ;
Sagap, Ismail ;
Tamil, Azmi Mohd ;
Ngah, Wan Zurinah Wan ;
Jamal, Rahman .
BMC MEDICAL GENOMICS, 2016, 9
[3]   TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer [J].
Banerjee, Rajat ;
Russo, Nickole ;
Liu, Min ;
Basrur, Venkatesha ;
Bellile, Emily ;
Palanisamy, Nallasivam ;
Scanlon, Christina S. ;
van Tubergen, Elizabeth ;
Inglehart, Ronald C. ;
Metwally, Tarek ;
Mani, Ram-Shankar ;
Yocum, Anastasia ;
Nyati, Mukesh K. ;
Castilho, Rogerio M. ;
Varambally, Sooryanarayana ;
Chinnaiyan, Arul M. ;
D'Silva, Nisha J. .
NATURE COMMUNICATIONS, 2014, 5
[4]   Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression [J].
Chang, Chia-Chi ;
Zhang, Chenyu ;
Zhang, Qingling ;
Sahin, Ozgur ;
Wang, Hai ;
Xu, Jia ;
Xiao, Yi ;
Zhang, Jian ;
Rehman, Sumaiyah K. ;
Li, Ping ;
Hung, Mien-Chie ;
Behbod, Fariba ;
Yu, Dihua .
ONCOTARGET, 2016, 7 (23) :35270-35283
[5]   A Novel Function of YWHAZ/β-Catenin Axis in Promoting Epithelial-Mesenchymal Transition and Lung Cancer Metastasis [J].
Chen, Ching-Hsien ;
Chuang, Show-Mei ;
Yang, Meng-Fang ;
Liao, Jiunn-Wang ;
Yu, Sung-Liang ;
Chen, Jeremy J. W. .
MOLECULAR CANCER RESEARCH, 2012, 10 (10) :1319-1331
[6]   Cancer Statistics in China, 2015 [J].
Chen, Wanqing ;
Zheng, Rongshou ;
Baade, Peter D. ;
Zhang, Siwei ;
Zeng, Hongmei ;
Bray, Freddie ;
Jemal, Ahmedin ;
Yu, Xue Qin ;
He, Jie .
CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (02) :115-132
[7]   PCMT1 is an unfavorable predictor and functions as an oncogene in bladder cancer [J].
Dong, Liming ;
Li, Yanpei ;
Xue, Dongwei ;
Liu, Yili .
IUBMB LIFE, 2018, 70 (04) :291-299
[8]   Quantifying the role of PSA screening in the US prostate cancer mortality decline [J].
Etzioni, Ruth ;
Tsodikov, Alex ;
Mariotto, Angela ;
Szabo, Aniko ;
Falcon, Seth ;
Wegelin, Jake ;
ditommaso, Dante ;
Karnofski, Kent ;
Gulati, Roman ;
Penson, David F. ;
Feuer, Eric .
CANCER CAUSES & CONTROL, 2008, 19 (02) :175-181
[9]   Recent Patterns of Prostate-Specific Antigen Testing for Prostate Cancer Screening in the United States [J].
Fedewa, Stacey A. ;
Ward, Elizabeth M. ;
Brawley, Otis ;
Jemal, Ahmedin .
JAMA INTERNAL MEDICINE, 2017, 177 (07) :1040-1042
[10]   The effect of the USPSTF PSA screening recommendation on prostate cancer incidence patterns in the USA [J].
Fleshner, Katherine ;
Carlsson, Sigrid V. ;
Roobol, Monique J. .
NATURE REVIEWS UROLOGY, 2017, 14 (01) :26-37