Structure-activity relationship studies of isoquinolinone type anticancer agent

被引：11
作者：
Cheon, SH
Park, JS
Lee, JY
Lee, YN
Yi, H
Chun, BH
Choi, BG
Cho, WJ
Choi, SU
Lee, CO
机构：
[1] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea
[2] Chonnam Natl Univ, Res Inst Drug Dev, Kwangju 500757, South Korea
[3] Korea Res Inst Chem Technol, Screening & Toxicol Res Ctr, Taejon 305606, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 04期
关键词：
isoquinolin-1-ones; 3-biphenylisoquinolin-1-ones; anticancer; cytotoxicity;
D O I：
10.1007/BF02975091
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Substituted isoquinolin-1-ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.
引用
收藏
页码：276 / 280
页数：5
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