Asymmetric aerobic oxidative NHC-catalysed synthesis of dihydropyranones utilising a system of electron transfer mediators

被引：36

作者：

Axelsson, A. ^{[1
]}

Hammarvid, E. ^{[1
]}

Ta, L. ^{[1
]}

Sunden, H. ^{[1
]}

机构：

[1] Chalmers Univ Technol, Chem & Chem Engn, Kemivagen 10, S-41296 Gothenburg, Sweden

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 77期

基金：

瑞典研究理事会;

关键词：

N-HETEROCYCLIC CARBENES; ENANTIOSELECTIVE MICHAEL REACTIONS; ALPHA; BETA-UNSATURATED ALDEHYDES; MOLECULAR-OXYGEN; 1,3-DICARBONYL COMPOUNDS; WACKER PROCESS; ACYL AZOLIUMS; ANNULATION; REARRANGEMENT; ACTIVATION;

D O I：

10.1039/c6cc06060a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the context of green chemistry, the replacement of high molecular weight stoichiometric oxidants with O-2 is most desirable but difficult. Here, we report the asymmetric aerobic oxidative synthesis of dihydropyranones. The oxidation is aided by a system of electron transfer mediators and is selective toward the homoenolate. The dihydropyranones can be isolated in high to excellent yields, with high ee (up to 95%).

引用

页码：11571 / 11574

页数：4

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